Secondary metabolites are small molecules that show large structural diversity and a broad
range of bioactivities. Some metabolites are attractive as drugs or pigments while others act …

Penicillium marneffei (synonym: Talaromyces marneffei) is the most important pathogenic
thermally dimorphic fungus in China and Southeastern Asia. The HIV/AIDS pandemic …

Background Polyketides are natural products with a wide range of biological functions and
pharmaceutical applications. Discovery and utilization of polyketides can be facilitated by …

Abstract ClusterMine360 (http://www. clustermine360. ca/) is a database of microbial
polyketide and non-ribosomal peptide gene clusters. It takes advantage of crowd-sourcing …

Fungal highly reducing polyketide synthases (HRPKSs) biosynthesize polyketides using a
single set of domains iteratively. Product release is a critical step in HRPKS function to …

Search of the protein database with the aflatoxin pathway polyketide synthase (PKS)
revealed putative PKSs in the pathogenic fungi Coccidioides immitis and Coccidioides …

Covering: the literature to 2006 Many virulence factors and bioactive compounds with
antifungal, antimicrobial, and antitumor properties are produced via the non-ribosomal …

The modular polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) have
been found to be involved in natural product synthesis in many microorganisms. Study on …

Truncated iterative polyketide synthase–nonribosomal peptide synthetase (PKS-NRPS)
megasynthases in which only the C domain is present are widespread in fungi, yet nearly all …

Background: Myxobacteria have been well established as a potent source for natural
products with biological activity. They produce a considerable variety of compounds which …