Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains
The product template (PT) domains, specifically in fungal non-reducing polyketide synthases
(NR-PKSs), mediate the regioselective cyclization of polyketides dominating the final …
(NR-PKSs), mediate the regioselective cyclization of polyketides dominating the final …
Exploration and exploitation of the environment for novel specialized metabolites
Highlights•Environments that are most promising sources of new bioactives were
identified.•New computational sequence binning tools improve large gene cluster …
identified.•New computational sequence binning tools improve large gene cluster …
Biosynthesis of sphinganine-analog mycotoxins
Sphinganine-analog mycotoxins (SAMT) are polyketide-derived natural products produced
by a number of plant pathogenic fungi and are among the most economically important …
by a number of plant pathogenic fungi and are among the most economically important …
Biosynthesis of hybrid peptide-polyketide natural products.
The structural and catalytic similarities between non-ribosomal peptide synthetase (NRPS)
and polyketide synthase (PKS) support the idea of combining individual NRPS and PKS …
and polyketide synthase (PKS) support the idea of combining individual NRPS and PKS …
Polyketide production by plant-associated pseudomonads
CL Bender, V Rangaswamy… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Polyketides constitute a huge family of structurally diverse natural products
including antibiotics, chemotherapeutic compounds, and antiparasitics. Most of the research …
including antibiotics, chemotherapeutic compounds, and antiparasitics. Most of the research …
A novel actinomycete strain de-replication approach based on the diversity of polyketide synthase and nonribosomal peptide synthetase biosynthetic pathways
A Ayuso, D Clark, I González, O Salazar… - Applied microbiology …, 2005 - Springer
The actinomycetes traditionally represent one of the most important sources for the
discovery of new metabolites with biological activity; and many of these are described as …
discovery of new metabolites with biological activity; and many of these are described as …
Identification of a hybrid PKS–NRPS required for the biosynthesis of NG-391 in Metarhizium robertsii
BGG Donzelli, SB Krasnoff, ACL Churchill… - Current genetics, 2010 - Springer
The fungal entomopathogen Metarhizium robertsii (formerly known as M. anisopliae var.
anisopliae) is a prolific producer of secondary metabolites of which very little is known at the …
anisopliae) is a prolific producer of secondary metabolites of which very little is known at the …
Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase
RJX Zawada, C Khosla - Chemistry & Biology, 1999 - cell.com
Background Polyketide synthases (PKSs) are bacterial multienzyme systems that synthesize
a broad range of natural products. The 'minimal'PKS consists of a ketosynthase, a chain …
a broad range of natural products. The 'minimal'PKS consists of a ketosynthase, a chain …
Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi
A Kaneko, Y Morishita, K Tsukada… - Organic & Biomolecular …, 2019 - pubs.rsc.org
Polyketide synthase (PKS) gene-guided genome mining in a cricket-associated fungus,
Penicillium soppi, revealed a cryptic biosynthetic gene cluster that contained a highly …
Penicillium soppi, revealed a cryptic biosynthetic gene cluster that contained a highly …
Novel Polyketide Synthase from Nectria haematococca
S Graziani, C Vasnier, MJ Daboussi - Applied and environmental …, 2004 - Am Soc Microbiol
We identified a polyketide synthase (PKS) gene, pksN, from a strain of Nectria
haematococca by complementing a mutant unable to synthesize a red perithecial pigment …
haematococca by complementing a mutant unable to synthesize a red perithecial pigment …