Actinobacteria such as streptomycetes are renowned for their ability to produce bioactive
natural products including nonribosomal peptides (NRPs) and polyketides (PKs). The …

Most known fungal polyketide synthases (PKSs) are iterative type I enzymes containing, as a
minimum, ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) …

Penicillium nordicum is a fungal species able to produce high amounts of ochratoxin A. A
10kb genomic DNA fragment of P. nordicum has been cloned which carries three long open …

Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …

Polyketides are a structurally diverse class of secondary metabolites produced by bacteria,
fungi, plants and animals. The fungal genus Fusarium includes agronomically important …

Type I polyketide synthases (PKSs) are complexes of large, multimodular enzymes that
catalyse biosynthesis of polyketide compounds via repetitive reaction sequences, during …

The structural diversity and complexity of marine natural products have made them a rich
and productive source of new bioactive molecules for drug development. The identification …

Polyketides (PKs) are a large group of natural products produced by microorganisms and
plants. They are biopolymers of acetate and other short carboxylates and are biosynthesized …

The structural and catalytic similarities between modular nonribosomal peptide synthetase
(NRPS) and polyketide synthase (PKS) inspired us to search for hybrid NRPS–PKS systems …

Complex polyketides comprise a large number of natural products that have broad
application in medicine and agriculture. They are produced in bacteria and fungi from large …