[HTML][HTML] Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS
KM Fisch - RSC advances, 2013 - pubs.rsc.org
Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS - RSC Advances (RSC
Publishing) DOI:10.1039/C3RA42661K Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/C3RA42661K Royal Society of Chemistry View PDF VersionPrevious …
Biosynthesis of non-melanin pigment by a divergent polyketide synthase in Metarhizium robertsii
Y Chen, P Feng, Y Shang, YJ Xu, C Wang - Fungal Genetics and Biology, 2015 - Elsevier
Fungal polyketide synthases (PKSs) and their related gene clusters are highly diversified at
both inter-and intra-specific levels. The most well characterized PKS enzymes include those …
both inter-and intra-specific levels. The most well characterized PKS enzymes include those …
[HTML][HTML] First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium …
Background The genome of P. marneffei, the most important thermal dimorphic fungus
causing respiratory, skin and systemic mycosis in China and Southeast Asia, possesses 23 …
causing respiratory, skin and systemic mycosis in China and Southeast Asia, possesses 23 …
Genomic insights into the distribution, genetic diversity and evolution of polyketide synthases and nonribosomal peptide synthetases
Polyketides and nonribosomal peptides are important secondary metabolites that exhibit
enormous structural diversity, have many pharmaceutical applications, and include a …
enormous structural diversity, have many pharmaceutical applications, and include a …
[HTML][HTML] Unique features of the ketosynthase domain in a nonribosomal peptide synthetase–polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1
CS Yun, K Nishimoto, T Motoyama, T Shimizu… - Journal of Biological …, 2020 - ASBMB
Many microbial secondary metabolites are produced by multienzyme complexes comprising
nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). The …
nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). The …
Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping
We reannotated the A. niger NR-PKS gene, e_gw1_19. 204, and its downstream R domain
gene, est_GWPlus_C_190476, as a single gene which we named dtbA. Heterologous …
gene, est_GWPlus_C_190476, as a single gene which we named dtbA. Heterologous …
Structural analysis of protein–protein interactions in type I polyketide synthases
Polyketide synthases (PKSs) are responsible for synthesizing a myriad of natural products
with agricultural, medicinal relevance. The PKSs consist of multiple functional domains of …
with agricultural, medicinal relevance. The PKSs consist of multiple functional domains of …
Manipulation of modular polyketide synthases
L Katz - Chemical reviews, 1997 - ACS Publications
Polyketides are a class of natural products synthesized by bacteria, fungi, and plants
through the successive condensation of simple carboxylic acids1 that have widespread use …
through the successive condensation of simple carboxylic acids1 that have widespread use …
[HTML][HTML] Repurposing modular polyketide synthases and non-ribosomal peptide synthetases for novel chemical biosynthesis
In nature, various enzymes govern diverse biochemical reactions through their specific three-
dimensional structures, which have been harnessed to produce many useful bioactive …
dimensional structures, which have been harnessed to produce many useful bioactive …
Functional expression of the Aspergillus flavus PKS–NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid
Y Seshime, PR Juvvadi, M Tokuoka, Y Koyama… - Bioorganic & medicinal …, 2009 - Elsevier
α-Cyclopiazonic acid (CPA) is an indole tetramic acid mycotoxin. Based on our identification
of the polyketide synthase–nonribosomal peptide synthase (PKS–NRPS) hybrid gene cpaA …
of the polyketide synthase–nonribosomal peptide synthase (PKS–NRPS) hybrid gene cpaA …