Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes
J Schümann, C Hertweck - Journal of biotechnology, 2006 - Elsevier
Fungal polyketides comprise a diverse group of secondary metabolites that play an
important role for drug discovery, as pigments, and as mycotoxins. Their biosynthesis is …
important role for drug discovery, as pigments, and as mycotoxins. Their biosynthesis is …
Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases
Small molecule secondary metabolites produced by organisms such as plants, bacteria, and
fungi form a fascinating and important group of natural products, many of which have shown …
fungi form a fascinating and important group of natural products, many of which have shown …
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes
E Skellam - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 1999 up to 2021 Fungal polyketides encompass a range of structurally diverse
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …
Type III polyketide synthases in natural product biosynthesis
Polyketides represent an important class of biologically active and structurally diverse
compounds in nature. They are synthesized from acyl‐coenzyme A substrates by polyketide …
compounds in nature. They are synthesized from acyl‐coenzyme A substrates by polyketide …
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
RJ Cox - Organic & biomolecular chemistry, 2007 - pubs.rsc.org
Fungi produce a wide variety of biologically active compounds. Among these, the
polyketides form a large and structurally diverse group. These compounds are synthesised …
polyketides form a large and structurally diverse group. These compounds are synthesised …
Navigating the fungal polyketide chemical space: from genes to molecules
The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …
enormously diverse array of natural products in fungi. These natural products, known as …
Fungal type III polyketide synthases
M Hashimoto, T Nonaka, I Fujii - Natural Product Reports, 2014 - pubs.rsc.org
Covering: 2005 to 2014 This article covers the literature on fungal type III polyketide
synthases (PKSs) published from 2005 to 2014. Since the first discovery of fungal type III …
synthases (PKSs) published from 2005 to 2014. Since the first discovery of fungal type III …
Heterologous expression systems for polyketide synthases
I Fujii - Natural product reports, 2009 - pubs.rsc.org
Polyketide synthases are the main biochemical machinery for the production of a structurally
diverse group of natural products, polyketides. Their heterologous expression enables …
diverse group of natural products, polyketides. Their heterologous expression enables …
Design and utility of oligonucleotide gene probes for fungal polyketide synthases
TP Nicholson, BAM Rudd, M Dawson, CM Lazarus… - Chemistry & biology, 2001 - cell.com
Background: Recent advances in the molecular biology of polyketide biosynthesis have
allowed the engineering of polyketide synthases and the biological ('combinatorial') …
allowed the engineering of polyketide synthases and the biological ('combinatorial') …
Evolutionary histories of type III polyketide synthases in fungi
JC Navarro-Muñoz, J Collemare - Frontiers in Microbiology, 2020 - frontiersin.org
Type III polyketide synthases (PKSs) produce secondary metabolites with diverse biological
activities, including antimicrobials. While they have been extensively studied in plants and …
activities, including antimicrobials. While they have been extensively studied in plants and …