Non-ribosomal peptide synthetases (NRPS) and type-I polyketide synthases (PKS-I) are
multimodular enzymes involved in biosynthesis of oligopeptide and polyketide secondary …

Covering: bacterial genome sequences to 2005 and post-genomic literature to June 2006 A
total of 223 complete bacterial genomes are analyzed, with 281 citations, for the presence of …

Considering that 70% of our planet's surface is covered by oceans, it is likely that
undiscovered biodiversity is still enormous. A large portion of marine biodiversity consists of …

Non-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) present in
bacteria and fungi are the major multi-modular enzyme complexes which synthesize …

Abstract ClusterMine360 (http://www. clustermine360. ca/) is a database of microbial
polyketide and non-ribosomal peptide gene clusters. It takes advantage of crowd-sourcing …

Highlights•Environments that are most promising sources of new bioactives were
identified.•New computational sequence binning tools improve large gene cluster …

Microbial natural products have played a key role in the development of clinical agents in
nearly all therapeutic areas. Recent advances in genome sequencing have revealed that …

Bacterial secondary metabolites are an important source of antimicrobial and cytostatic
drugs. These molecules are often synthesized in a stepwise fashion by multimodular …

Many bacterial and fungal secondary metabolites are produced by polyketide synthases
(PKS) and non-ribosomal peptide synthetases (NRPS). Recently, it has been discovered …

Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are large
enzymes responsible for the biosynthesis of medically and ecologically important secondary …