Tumors are dynamic pseudoorgans that contain numerous cell types interacting to create a
unique physiology. Within this network, the malignant cells encounter many challenges and …

Highlights•Differential vasculature perfusion and oncogenic load promote tumor metabolic
heterogeneity.•Activated cancer associated fibroblasts and pancreatic stellate cells supply …

Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

ABSTRACT A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated
once cells have accumulated alterations in signaling pathways that control metabolism and …

The role of metabolites exchanged in the tumor microenvironment is largely thought of as
fuels to drive the increased biosynthetic and bioenergetic demands of growing tumors …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

Cancer cells have enhanced metabolic needs due to their rapid proliferation. Moreover,
throughout their progression from tumor precursors to metastases, cancer cells face …

Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …

Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …

Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …