Physiological and therapeutic roles of peroxisome proliferator-activated receptors

J Berger, JA Wagner - Diabetes technology & therapeutics, 2002 - liebertpub.com
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor
isoforms, including PPAR γ, PPAR α, and PPAR δ, encoded by different genes. PPARs are …

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

KD Wagner, N Wagner - Pharmacology & therapeutics, 2010 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors. They function as
ligand activated transcription factors. They exist in three isoforms, PPARα, PPARβ (formerly …

The mechanisms of action of PPARs

J Berger, DE Moller - Annual review of medicine, 2002 - annualreviews.org
▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …

Pleiotropic actions of peroxisome proliferator–activated receptors in lipid metabolism and atherosclerosis

O Barbier, IP Torra, Y Duguay, C Blanquart… - … , and vascular biology, 2002 - Am Heart Assoc
Peroxisome proliferator–activated receptors (PPARs) are nuclear receptors activated by fatty
acids and derivatives. Although PPARα mediates the hypolipidemic action of fibrates …

Biology and therapeutic applications of peroxisome proliferator-activated receptors

MP Menendez-Gutierrez, T Roszer… - Current topics in …, 2012 - ingentaconnect.com
Peroxisome proliferator-activated receptors (PPARs) are ligand dependent transcription
factors. The three mammalian PPARs are key regulators of fatty acid and lipoprotein …

[PDF][PDF] Peroxisome proliferator-activated receptors (PPARS): a target with a broad therapeutic potential for human diseases: an overview

MP Singh, D Pathak, GK Sharma… - …, 2011 - pharmacologyonline.silae.it
Increasing attention has been focused on the role of peroxisome proliferator-activated
receptors (PPARs) in the past decade. Compelling data have begun to unite work from …

Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease

E Robinson, DJ Grieve - Pharmacology & therapeutics, 2009 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear
transcription factors that belong to the nuclear receptor superfamily. Three isoforms of PPAR …

The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity

P Ferré - Diabetes, 2004 - Am Diabetes Assoc
Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to
the superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They …

Peroxisome proliferator–activated receptors as transcriptional nodal points and therapeutic targets

JD Brown, J Plutzky - Circulation, 2007 - Am Heart Assoc
Peroxisome proliferator–activated receptors (PPARs) are ligand-activated transcription
factors involved in the transcriptional regulation of key metabolic pathways such as lipid …

Physiological functions of peroxisome proliferator-activated receptor β

JG Neels, PA Grimaldi - Physiological reviews, 2014 - journals.physiology.org
The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …