[HTML][HTML] Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization

D Zhao, C Xue, Y Yang, J Li, X Wang, Y Chen… - Biomedicine & …, 2022 - Elsevier
Liver fibrosis is an important pathologic process in response to chronic or repetitive liver
injury. It can advance to liver cirrhosis. Both peroxisome proliferator-activated receptor …

[PDF][PDF] Reticulon 4B (Nogo‐B) is a novel regulator of hepatic fibrosis

D Zhang, T Utsumi, HC Huang, L Gao… - …, 2011 - Wiley Online Library
Nogo‐B, also known as Reticulon 4B, plays important roles in vascular injuries. Its function
in the liver is not understood. The aim of this study was to characterize Nogo‐B in liver …

[HTML][HTML] Nogo-B is a key mediator of hepatic ischemia and reperfusion injury

J Rao, F Cheng, H Zhou, W Yang, J Qiu, C Yang, X Ni… - Redox biology, 2020 - Elsevier
Nogo-B is an endoplasmic reticulum-residential protein with distinctive functions in different
diseases. However, it remains unclear the role of Nogo-B in liver sterile inflammatory injury …

[PDF][PDF] An endoplasmic reticulum protein, Nogo‐B, facilitates alcoholic liver disease through regulation of kupffer cell polarization

JK Park, M Shao, MY Kim, SK Baik, MY Cho… - …, 2017 - Wiley Online Library
Nogo‐B (Reticulon 4B) is an endoplasmic reticulum (ER) resident protein that regulates ER
structure and function. Because ER stress is known to induce M2 macrophage polarization …

Nogo‐B: A potential indicator for hepatic cirrhosis and regulator in hepatic stellate cell activation

R Men, M Wen, X Dan, Y Zhu, W Wang, J Li… - Hepatology …, 2015 - Wiley Online Library
Aim To evaluate plasma N ogo‐B levels in liver cirrhotic patients and declare a novel
molecular basis by which N ogo‐B modulates hepatic stellate cell (HSC) activation. Methods …

[HTML][HTML] Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice

K Tashiro, A Satoh, T Utsumi, C Chung… - The American Journal of …, 2013 - Elsevier
Nogo-B (reticulon 4B) accentuates hepatic fibrosis and cirrhosis, but the mechanism
remains unclear. The aim of this study was to identify the role of Nogo-B in hepatic stellate …

6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice

K Gong, Z Zhang, S Chen, X Zhu, M Wang… - Acta Pharmacologica …, 2023 - nature.com
Excessive fructose consumption increases hepatic de novo lipogenesis, resulting in cellular
stress, inflammation and liver injury. Nogo-B is a resident protein of the endoplasmic …

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

JX Jiang, X Chen, N Serizawa, C Szyndralewiez… - Free Radical Biology …, 2012 - Elsevier
Reactive oxygen species (ROS) play a key role in chronic liver injury and fibrosis. Homologs
of NADPH oxidases (NOXs) are major sources of ROS, but the exact role of the individual …

Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation

T Lan, T Kisseleva, DA Brenner - PloS one, 2015 - journals.plos.org
Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate
oxidase (NOX) play a key role in liver injury and fibrosis. Previous studies demonstrated that …

Nobiletin alleviates non-alcoholic steatohepatitis in MCD-induced mice by regulating macrophage polarization

S Wang, T Lan, H Sheng, F Zheng, M Lei… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder that is characterized by
chronic activation of the hepatic inflammatory response and subsequent liver damage. The …