From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

JN Feige, L Gelman, L Michalik, B Desvergne… - Progress in lipid …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …

PPARs: fatty acid sensors controlling metabolism

L la Cour Poulsen, M Siersbæk, S Mandrup - Seminars in cell & …, 2012 - Elsevier
The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …

Transcription coactivators for peroxisome proliferator-activated receptors

S Yu, JK Reddy - Biochimica et Biophysica Acta (BBA)-molecular and …, 2007 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) regulate diverse biological processes
such as development, differentiation, neoplastic conversion, inflammation and wound …

Kinase signaling cascades that modulate peroxisome proliferator-activated receptors

L Gelman, L Michalik, B Desvergne, W Wahli - Current Opinion in Cell …, 2005 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid
and glucose homeostasis, inflammation and wound healing. In addition to ligand binding …

[HTML][HTML] PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

T Varga, Z Czimmerer, L Nagy - … et Biophysica Acta (BBA)-Molecular Basis …, 2011 - Elsevier
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …

Peroxisome proliferator-activated receptor α target genes

S Mandard, M Müller, S Kersten - Cellular and Molecular Life Sciences …, 2004 - Springer
Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the
superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic …

Be fit or be sick: peroxisome proliferator-activated receptors are down the road

B Desvergne, L Michalik, W Wahli - Molecular Endocrinology, 2004 - academic.oup.com
Investigating metabolism by unveiling the functions of the nuclear receptors peroxisome
proliferator-activated receptors (PPARs) in the numerous intricate pathways ensuring energy …

Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice

IP Torra, G Chinetti, C Duval, JC Fruchart… - Current Opinion in …, 2001 - journals.lww.com
Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors
that control energy homeostasis through genomic actions. Over the past few years …

Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism

SA Smith - Biochemical Society Transactions, 2002 - portlandpress.com
Peroxisome proliferator-activated receptors (PPARs) are members of the superfamily of
ligand-activated nuclear transcription factors. Three PPAR subtypes, PPARα, PPARδ …

An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer

L Gelman, JC Fruchart, J Auwerx - Cellular and Molecular Life Sciences …, 1999 - Springer
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and have been
initially described as molecular targets for compounds which induce peroxisome …