From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

JN Feige, L Gelman, L Michalik, B Desvergne… - Progress in lipid …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …

[PDF][PDF] The role of PPARgamma in cardiovascular diseases

M Kvandová, M Majzúnová, I Dovinová - Physiol Res, 2016 - academia.edu
The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of
ligand-activated transcription factors. PPARγ acts as a nutrient sensor that regulates several …

Modulation of Hepatic Inflammatory Risk Markers of Cardiovascular Diseases by PPAR–α Activators: Clinical and Experimental Evidence

A Zambon, P Gervois, P Pauletto… - … and Vascular Biology, 2006 - Am Heart Assoc
Atherosclerosis is a long-term chronic inflammatory disease associated with increased
concentrations of inflammatory hepatic markers, such as CRP and fibrinogen, and of …

Be fit or be sick: peroxisome proliferator-activated receptors are down the road

B Desvergne, L Michalik, W Wahli - Molecular Endocrinology, 2004 - academic.oup.com
Investigating metabolism by unveiling the functions of the nuclear receptors peroxisome
proliferator-activated receptors (PPARs) in the numerous intricate pathways ensuring energy …

PPARs: nuclear receptors controlled by, and controlling, nutrient handling through nuclear and cytosolic signaling

M Moreno, A Lombardi, E Silvestri, R Senese… - PPAR …, 2010 - Wiley Online Library
Peroxisome proliferator‐activated receptors (PPARs), which are known to regulate lipid
homeostasis, are tightly controlled by nutrient availability, and they control nutrient handling …

Physiological and therapeutic roles of peroxisome proliferator-activated receptors

J Berger, JA Wagner - Diabetes technology & therapeutics, 2002 - liebertpub.com
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor
isoforms, including PPAR γ, PPAR α, and PPAR δ, encoded by different genes. PPARs are …

[HTML][HTML] PPARs and metabolic disorders associated with challenged adipose tissue plasticity

P Corrales, A Vidal-Puig, G Medina-Gómez - International Journal of …, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are members of a family of nuclear
hormone receptors that exert their transcriptional control on genes harboring PPAR …

Peroxisome proliferator‐activated receptor‐γ: too much of a good thing causes harm

TA Cock, SM Houten, J Auwerx - EMBO reports, 2004 - embopress.org
The nuclear receptor peroxisome proliferator‐activated receptor‐γ (PPARγ) helps to
translate 'what you eat'into 'what you are'because it allows dietary fatty acids (PPARγ …

PPARγ and its ligands: therapeutic implications in cardiovascular disease

L Villacorta, FJ Schopfer, J Zhang, BA Freeman… - Clinical …, 2009 - portlandpress.com
The relevance of PPARγ (peroxisome-proliferator-activated receptor γ) as an important
therapeutic target for the treatment of diabetes arises from its hypoglycaemic effects in …

Long-chain polyunsaturated fatty acids regulation of PPARs, signaling: Relationship to tissue development and aging

F Echeverría, M Ortiz, R Valenzuela… - … Leukotrienes and Essential …, 2016 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as
ligand-dependent transcription factors that can be activated by different types of fatty acids …