PPARs and metabolic disorders associated with challenged adipose tissue plasticity

P Corrales, A Vidal-Puig, G Medina-Gómez - International Journal of …, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are members of a family of nuclear
hormone receptors that exert their transcriptional control on genes harboring PPAR …

PPARs-orchestrated metabolic homeostasis in the adipose tissue

C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
It has been more than three decades since peroxisome proliferator-activated receptors
(PPARs) were first discovered. Many investigations have revealed the central regulators of …

Deciphering the roles of PPARγ in adipocytes via dynamic change of transcription complex

X Ma, D Wang, W Zhao, L Xu - Frontiers in endocrinology, 2018 - frontiersin.org
Peroxisome proliferator-activated receptor γ (PPARγ), a ligand-dependent transcription
factor highly expressed in adipocytes, is a master regulator of adipogenesis and lipid …

Pivotal roles of peroxisome proliferator-activated receptors (PPARs) and their signal cascade for cellular and whole-body energy homeostasis

S Lamichane, B Dahal Lamichane… - International journal of …, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor
superfamily, are important in whole-body energy metabolism. PPARs are classified into …

Peroxisome proliferator-activated receptor-γ: master regulator of adipogenesis and obesity

X Shao, M Wang, X Wei, S Deng, N Fu… - Current stem cell …, 2016 - ingentaconnect.com
Obesity, which is a key risk for the development of hyperglycemia, hypertension,
hyperlipidemia and insulin resistance and is totally referred to as the metabolic disorders …

Be fit or be sick: peroxisome proliferator-activated receptors are down the road

B Desvergne, L Michalik, W Wahli - Molecular Endocrinology, 2004 - academic.oup.com
Investigating metabolism by unveiling the functions of the nuclear receptors peroxisome
proliferator-activated receptors (PPARs) in the numerous intricate pathways ensuring energy …

PPARs: diverse regulators in energy metabolism and metabolic diseases

YX Wang - Cell research, 2010 - nature.com
The nuclear receptor PPARs are fundamentally important for energy homeostasis. Through
their distinct yet overlapping functions and tissue distribution, the PPARs regulate many …

PPARs and adipocyte function

C Christodoulides, A Vidal-Puig - Molecular and cellular endocrinology, 2010 - Elsevier
For long viewed as passive lipid storage depots, adipocytes are now recognised as key
players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last …

[HTML][HTML] Integrated physiology and systems biology of PPARα

S Kersten - Molecular metabolism, 2014 - Elsevier
Abstract The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription
factor that plays a major role in metabolic regulation. This review addresses the functional …

[HTML][HTML] Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors

SD Clarke, P Thuillier, RA Baillie, X Sha - The American journal of clinical …, 1999 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription
factors that belong to the steroid receptor superfamily. This family of PPARs includes …