Dual stimuli-responsive release of aptamer AS1411 decorated erlotinib loaded chitosan nanoparticles for non-small-cell lung carcinoma therapy

K Saravanakumar, A Sathiyaseelan… - Carbohydrate …, 2020 - Elsevier
… The present work was developed the pH dependent-aptamer AS1411 (APT) decorated
and erlotinib (En) loaded chitosan nanoparticles (CSNPs) for promising non-small-cell lung …

AS1411 aptamer-functionalized chitosan-silica nanoparticles for targeted delivery of epigallocatechin gallate to the SKOV-3 ovarian cancer cell lines

L Alizadeh, E Alizadeh, A Zarebkohan… - Journal of Nanoparticle …, 2020 - Springer
… of nanoparticle surfaces. In this study, we used chitosan polymer for the attachment of aptamer
… Herein, we have synthesized SiO2@CS nanoparticles which are loaded EGCG and then …

Improving Chemotherapy Effectiveness: Utilizing CuS Nanoparticles Coated with AS1411 Aptamer and Chitosan for Targeted Delivery of Doxorubicin to Cancerous …

M Imanimoghadam, E Yaghoobi, F Alizadeh… - Journal of …, 2024 - Elsevier
AS1411 triggers macropinocytosis in … of AS1411 aptamer and NPs attached to this aptamer.
It has been demonstrated that the AS1411 aptamer and nanoparticles modified with AS1411

AS1411 aptamer/RGD dual functionalized theranostic chitosan-PLGA nanoparticles for brain cancer treatment and imaging

M Chauhan, S Shekhar, B Yadav, V Garg, R Dutt… - Biomaterials …, 2024 - Elsevier
… -chitosan, TPGS-RGD and TPGS-AS1411 aptamer conjugates for making PLGA nanoparticle
… The developed nanoparticles have shown an average particle size <200 nm, spherical in …

Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21

F Khatami, MM Matin, NM Danesh, AR Bahrami… - Carbohydrate …, 2021 - Elsevier
… The antagomiR (antimiR-21) and AS1411 aptamer were attached on the surface of
chitosan-coated MSNs. It has been demonstrated that free antimiR-21 is unable to enter the cells …

Novel nanosized AS1411chitosan–BODIPY conjugate for molecular fluorescent imaging

S Taki, MS Ardestani - International Journal of Nanomedicine, 2019 - Taylor & Francis
… In this study, for the first time, AS1411 aptamer was conjugated to the chitosan nano-… For
this purpose, chitosan nanoparticles were conjugated with the aptamer using DMSO, EDC and …

Recent development of aptamer conjugated chitosan nanoparticles as cancer therapeutics

A Sheikh, S Md, NA Alhakamy, P Kesharwani - International Journal of …, 2022 - Elsevier
… The micelles were decorated with AS1411 aptamer and poly (ethylene glycol) (PEG).
The PEG chains shielded the decorated nanomicelles from the effect of nucleases. As a …

Glutathione responsive chitosan-thiolated dextran conjugated miR-145 nanoparticles targeted with AS1411 aptamer for cancer treatment

FSM Tekie, M Soleimani, A Zakerian, M Dinarvand… - Carbohydrate …, 2018 - Elsevier
… nucleolin aptamer (AS1411) as a targeting agent to enhance the uptake of nanoparticles by
… Thiolated chitosan nanoparticles as an oral delivery system for amikacin: In vitro and ex vivo …

Aptamer-functionalized chitosan-coated gold nanoparticle complex as a suitable targeted drug carrier for improved breast cancer treatment

M Shahidi, O Abazari, P Dayati, A Bakhshi… - Nanotechnology …, 2022 - degruyter.com
… In the following research, we specifically assessed the feasibility of a novel AS-1411-chitosan
(CS)-gold nanoparticle (AuNPs) delivery system to carry methotrexate (MTX) into the …

Therapeutic applications of AS1411 aptamer, an update review

R Yazdian-Robati, P Bayat, F Oroojalian… - International journal of …, 2020 - Elsevier
… Targeting nucleolin by compounds such as AS1411 aptamer can reduce tumor cell growth.
In … the G-rich AS1411 aptamer in the field of cancer therapy mainly over the past three years. …