… experimental mixture toxicity against the combined effect model(s) selected. … mixture
toxicity testing and data analysis protocols used, removal of the minimum effect parameter …

… Binary-mixture studies often … -mixture toxicity experiments in terms of deviation from the
reference model of concentration addition (CA), dose-level dependence, and isobole asymmetry. …

… mixture toxicity and clarify the interaction between mixture components. The risk assessment
of mixtures … impact the mixture toxicity (such as multiple chemicals, species, mechanisms of …

… been used, eg one allowing for asymmetry or hormesis (increase in response at … mixtures
the CA assumption corresponds to a straight line isobole, whereas our model has a parameter …

… is the effective concentration of the mixture predicted by any one of … mixture obtained from
toxicity testing. The Observed values in this study are calculated as a mean of toxicity mixtures …

… For example, the degree of asymmetry in the third example was not reproducible in three …
the interaction parameters are easily converted to the sum of toxic units for a 50:50%-mixture, …

… the standard four-parameter logistic function (which employed the minimum … parameter but
not the asymmetry parameter) and suggested that changes in slope, asymmetry, and toxicity …

… -derived analyses, and the slope and asymmetry values for the two mixture toxicity
models used in this study are publicly available from the OSF repository (https://osf.io/2nvdw/). …

… toxicity of multicomponent mixtures reasonably, interactions may limit the predictive capability
when a few compounds dominate a mixture. … to a full range of mixtures of the similar acting …

… are to be viewed as a true low concentration phenomenon of many toxicants, then this study
represents a first step towards an incorporation of hormesis into mixture-toxicity evaluations. …