… on occurrence and role of TMS genes in the published bacterial genome sequences. For
these reasons, we surveyed bacterial genomes for the presence of TMS genes using either the …

… of microbial genomes led to discovery of novel bioactive compounds synthesized by NRPS
and PKS-I through genome-… field which directly studies microbial genomes or specific gene …

… Bacterial genome coverage is heavily biased toward pathogenic strains. Recent efforts
have attempted to obtain genomes from the poorly covered phylogenetic branches [18]. This …

… peptide (NRP) structures encoded in microbial genomes. PKs/… by polyketide synthases (PKS)
and nonribosomal peptide synthetases (… The integrative analysis of genomic and chemical …

… Microbial genomes are now sequenced at an unprecedented rate and this vast quantity of
biological information can be analyzed through genome … studies microbial genomes and their …

… understanding of genetics and … peptides. Since these natural products are derived from
enzymatic systems called polyketide synthases (PKSs) and nonribosomal peptide synthetases (…

… well as being abundant in microbial genomes/metagenomes. With ever cheaper sequencing
technologies and improved bioinformatic prediction tools, genomic mining approaches will …

… genomic DNA, by using degenerate oligonucleotides corresponding to highly conserved motifs
in peptide synthetases (… residues) in bacterial and fungal peptide synthetases were found …

… by nonribosomal peptide synthetases against microbial pathogens… screening, complete
bacterial genomes were obtained from the … The algorithms we used for predicting the peptide …

… In this work, an architecturally unusual biosynthetic gene cluster is described that resides
on the genome of an uncultured bacterial symbiont of Paederus fuscipes beetles. …