Prognostic value of CXCR2 in breast cancer

F Boissière-Michot, W Jacot, J Fraisse, S Gourgou… - Cancers, 2020 - mdpi.com
breast cancers (TNBC). Our hypothesis was that CXCR2 expression could also be altered
in breast cancer… Here, we have analyzed the potential role of CXCR2 in breast cancer in a …

CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2

H Xu, F Lin, Z Wang, L Yang, J Meng, Z Ou, Z Shao… - Cancer letters, 2018 - Elsevier
… causes of breast cancer death. We show here that the chemokine receptor CXCR2 was
overexpressed in breast cancer cell … These data suggest that CXCR2 induces breast cancer cell …

CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways

T Sobolik, Y Su, S Wells, GD Ayers… - Molecular biology of …, 2014 - Am Soc Cell Biol
… that CXCR4 expression induced expression of CXCR2 and ligands for CXCR2 in 3D rBM
cultures. Inhibition of CXCR2 in combination with inhibition of CXCR4 induced reversion of the …

Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells

B Sharma, ML Varney, S Saxena, L Wu, RK Singh - Cancer letters, 2016 - Elsevier
… between CXCR2 signaling and … of CXCR2 signaling in breast cancer therapy resistance
and suggests that targeting this signaling may help reduce the problem of resistance in cancer. …

[HTML][HTML] Role of chemokine receptor CXCR2 expression in mammary tumor growth, angiogenesis and metastasis

KC Nannuru, B Sharma, ML Varney… - Journal of …, 2011 - ncbi.nlm.nih.gov
… We evaluated the functional role of CXCR2 in breast cancer by stably downregulating the …
It has been reported that blocking CXCR2 inhibited pancreatic cancer cell induced

Pivotal role for Cxcr2 in regulating tumor-associated neutrophil in breast cancer

C Timaxian, CFA Vogel, C Orcel, D Vetter, C Durochat… - Cancers, 2021 - mdpi.com
… G−CSF, which expression is increased in PyMT−Cxcr2−/− TANs, is able to induce … also
induces the release of Prok2 by neutrophils, which in turn promotes angiogenesis and cancer cell …

The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis

R Romero-Moreno, KJ Curtis, TR Coughlin… - Nature …, 2019 - nature.com
… Our results demonstrate that CXCL5 is sufficient to induce cancer cell proliferation in bone
… with breast cancer metastasis to bone for CXCL5 and CXCR2 by IHC. CXCL5 and CXCR2

Targeting CXCR2 enhances chemotherapeutic response, inhibits mammary tumor growth, angiogenesis, and lung metastasis

B Sharma, DM Nawandar, KC Nannuru… - Molecular cancer …, 2013 - AACR
… of CXCR2 knockdown in mediating chemotherapy-inducedCXCR2 ligands axis plays an
important role in breast cancer therapy resistance. We observed that aggressive breast cancer

CXCR2 receptor: regulation of expression, signal transduction, and involvement in cancer

J Korbecki, P Kupnicka, M Chlubek, J Gorący… - International Journal of …, 2022 - mdpi.com
… leukemia [101], invasive ductal breast cancer [102], colorectal cancer [103], esophageal …
tumor microenvironment, as CXCR2 ligands secreted by cancer cells induce senescence of …

Triple-negative breast cancer cells recruit neutrophils by secreting TGF-β and CXCR2 ligands

…, Y Li, C Johnson, D Cai, JL Smith, CA Parent - Frontiers in …, 2021 - frontiersin.org
… We found that TCM-induced neutrophil migration is … based on their ability to induce polarized
neutrophil morphology revealed … of breast cancer cells and their ability to induce neutrophil …