Positive and negative regulation of NF-κB by COX-2: roles of different prostaglandins
B Poligone, AS Baldwin - Journal of Biological Chemistry, 2001 - ASBMB
… of NF-κB. In this report we demonstrate COX-2 expression inhibits nuclear translocation of
NF-κB, and we confirm that the cyclopentenone prostaglandins inhibit NF-κB. In addition, we …
NF-κB, and we confirm that the cyclopentenone prostaglandins inhibit NF-κB. In addition, we …
Evidence for involvement of NF-κB in the transcriptional control of COX-2 gene expression by IL-1β
… that the two NF-κB subunits, p50 and p65, synergistically activate a −917/+49 COX-2 promoter
… via transcriptional activation of COX-2 and provide evidence that this may involve NF-κB. …
… via transcriptional activation of COX-2 and provide evidence that this may involve NF-κB. …
… mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB …
YJ Surh, KS Chun, HH Cha, SS Han, YS Keum… - Mutation Research …, 2001 - Elsevier
… in both COX-2 mRNA and … of COX-1 was not influenced by NF-κB blockade in this study.
Acetylsalicylic acid (aspirin), a non-selective COX inhibitor, was found to suppress the NF-κB …
Acetylsalicylic acid (aspirin), a non-selective COX inhibitor, was found to suppress the NF-κB …
Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-κB inactivation in RAW 264.7 macrophage cells
JB Kim, AR Han, EY Park, JY Kim, W Cho… - Biological and …, 2007 - jstage.jst.go.jp
We previously reported that poncirin, a flavanone glycoside isolated from the EtOAc extract
of the dried immature fruits of Poncirus trifoliata, is an anti-inflammatory compound that …
of the dried immature fruits of Poncirus trifoliata, is an anti-inflammatory compound that …
Nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy
… Nuclear factor-kappaB (NF-κB) and cyclooxygenase 2 (COX-2) are … The samples were stained
for NF-κB and COX-2 using routine … the expression of NF-κB and COX-2 in the human oral …
for NF-κB and COX-2 using routine … the expression of NF-κB and COX-2 in the human oral …
Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue
MP Charalambous, T Lightfoot, V Speirs… - British journal of …, 2009 - nature.com
… The mechanism of COX-2 induction in these tumours is not fully understood, … (NF)-κB and
COX-2. We hypothesised an association between COX-2 expression and NF-κB-p65, NF-κB-…
COX-2. We hypothesised an association between COX-2 expression and NF-κB-p65, NF-κB-…
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-κB activation through inhibition of activation of IκBα kinase and Akt in human non-small cell …
S Shishodia, D Koul, BB Aggarwal - The Journal of Immunology, 2004 - journals.aai.org
… suppress NF-κB activation induced by a variety of agents through inhibition of IKK and Akt.
We also demonstrate the suppression of NF-κB-regulated gene expression including COX-2 …
We also demonstrate the suppression of NF-κB-regulated gene expression including COX-2 …
Spinal NF‐kB activation induces COX‐2 upregulation and contributes to inflammatory pain hypersensitivity
KM Lee, BS Kang, HL Lee, SJ Son… - European Journal of …, 2004 - Wiley Online Library
… COX-2 upregulation following CFA injection, our results suggest that IL-1β-induced spinal
COX-2 … inflammation are mediated through the activation of the NF-kB-associated pathways. …
COX-2 … inflammation are mediated through the activation of the NF-kB-associated pathways. …
Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-κB pathways
S Lee, S Shin, H Kim, S Han, K Kim, J Kwon… - Journal of …, 2011 - Springer
… suppressed PGE 2 production via inhibition of COX-2 enzyme activity and … NF-κB is important
for the expression of immune and inflammatory genes. The activated NF-κB then binds κB …
for the expression of immune and inflammatory genes. The activated NF-κB then binds κB …
The effect of age on cyclooxygenase-2 gene expression: NF-κB activation and IκBα degradation
HJ Kim, KW Kim, BP Yu, HY Chung - Free Radical Biology and Medicine, 2000 - Elsevier
… that COX-2 is upregulated by aging in kidney, and that this up-modulation of NF-κB activity is
… Based on these data, we conclude that an increase in NF-κB binding activity during aging is …
… Based on these data, we conclude that an increase in NF-κB binding activity during aging is …
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