The COX-2/PGE 2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

A Greenhough, HJM Smartt, AE Moore… - …, 2009 - academic.oup.com
… In this review, we discuss the impact of the COX-2/PGE 2 pathway on colorectal cancer …
regulators of COX–prostaglandin signalling and novel roles for COX-2/PGE 2 signalling in …

Inflammation in gastric cancer: Interplay of the COX2/prostaglandin E2 and Toll‐like receptor/MyD88 pathways

K Echizen, O Hirose, Y Maeda, M Oshima - Cancer science, 2016 - Wiley Online Library
… the COX-2/PGE 2 pathwayCOX-2/PGE 2 -induced gastritis and gastric tumor development.16
Accordingly, it is possible that the interplay of the COX-2/PGE 2 and TLR/MyD88 pathways

Role of COX-2/PGE2 mediated inflammation in oral squamous cell carcinoma

WHS Nasry, JC Rodriguez-Lecompte, CK Martin - Cancers, 2018 - mdpi.com
… A significant amount of research indicates that the cyclooxygenase/prostaglandin E2 (PGE2)
pathway of inflammation contributes to the development and progression of a variety of …

COX-2/PGE2 pathway inhibits the ferroptosis induced by cerebral ischemia reperfusion

Y Xu, Y Liu, K Li, D Yuan, S Yang, L Zhou, Y Zhao… - Molecular …, 2022 - Springer
… between ferroptosis and PGE2, we explored how the COX-2/PGE2 pathway would respond
after … We first examined the PGE2 release. Figure 3D showed that the elevation of PGE2 after …

Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures

MS Oliveira, AF Furian, LFF Royes, MR Fighera… - Epilepsy research, 2008 - Elsevier
… Therefore, in the current study, we investigate the role COX-2/PGE 2 pathway in the
behavioral and electrographic seizures induced by PTZ, aiming to shed some light on these …

The COX-2–PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas

J Wei, J Zhang, D Wang, B Cen, JD Lang… - Cancer Prevention …, 2022 - AACR
… cancer is that the presence of COX-2–derived PGE 2 might attenuate their effect by reducing
… In this study, we investigate whether activation of the COX-2-PGE 2 pathway induces tumor …

Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells

KS Lee, HJ Lee, KS Ahn, SH Kim, D Nam, DK Kim… - Cancer letters, 2009 - Elsevier
… , thereby implicating the critical role of COX-2 pathway in IS induced apoptosis. Taken …
COX-2/PGE 2 pathway and then induces apoptosis mainly via mitochondrial dependent pathway

The Cyclooxygenase-2–Prostaglandin E2 Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts

M Dagouassat, JM Gagliolo, S Chrusciel… - American journal of …, 2013 - atsjournals.org
… PGE 2 and COX-2 could explain the increased COX-2 in senescent COPD fibroblasts
because our results and other studies showed that PGE 2 can induce COX-2 expression (37). …

Cyclooxygenase-2-Prostaglandin E2 pathway: A key player in tumor-associated immune cells

K Jin, C Qian, J Lin, B Liu - Frontiers in oncology, 2023 - frontiersin.org
… the COX-2-PGE2 pathway affects tumor-associated immune cells. Given the significance of
this pathway … In conclusion, the COX-2-PGE2 pathway not only is an effective target for tumor …

Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages

MD Diaz-Munoz, IC Osma-Garcia, M Fresno… - Biochemical …, 2012 - portlandpress.com
… Our results show that PGE 2 induces transcriptional activation of both COX-2 and mPGES-1 …
pathway. This positive-feedback regulation of the PGE 2 -synthesizing enzymes COX-2 and …