… In summary, targeted therapies against COX‐2 offer a promising future in oncology treatment,
considering its involvement in multiple signaling pathways in tumor development. There is …

… a new class of COX-2 selective inhibitors (COXIBs) preferentiallyinhibit the COX-2 enzyme.
This review summarizes our current understanding ofthe role of COX-1 and COX-2 in normal …

… Such a clearly identified target could be relevant for anticancer therapy. COX-2 is a target
for anticancer therapy, but more than solely a target, COX-2 is also a signal that points to key …

Antiangiogenic agents targeting the vascular … COX-2/PGE 2 axis contributes to VEGF-independent
tumor angiogenesis. Thus, COX-2/PGE 2 inhibition may potentiate VEGF therapies…

… therapy and this portrays Cox2 blocking as an important remedy to combine with hormone
therapy. … Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional …

… HER-2 or COX-2 positivity and outcome in subjects with invasive bladder cancer. However,
HER-2-… that molecular-targeted therapy against HER-2 could be an effective therapy. Further …

… cyclooxygenase-2 (COX-2) plays an important role in the pathogenesis of non–small-cell
lung cancers (NSCLC).COX-2 is one of two isoforms of COX … COX-2 derived PGE2 promotes …

… markers for innovative molecularly targeted therapies such as COX-2, c-KIT and HER-2/neu
in uterine carcinosarcomas. We found that COX-2, c-KIT and HER-2/neu are expressed in …

… Disruption of stroma functions, eg angiogenesis, has evolved into a promising target for
cancer therapies. Since stromal cells are genetically stable, stroma-targeted therapies seem to …

… of COX-2 may be a consequence of the fact that COX-2 generates a precursor PG called PGH
2 , … depending on the PG synthase expressed by the target cell. Thus, specific blockade of …