Lung cancer and cyclooxygenase-2

JE Castelao, RD Bart III, CA DiPerna… - The Annals of thoracic …, 2003 - Elsevier
… A growing body of evidence indicates COX-2 plays a key role in lung cancer, and can … 2
inhibitor medications offers a unique opportunity to interfere with the development of lung cancer

Expression of cyclooxygenase-2 in human lung carcinoma

H Wolff, K Saukkonen, S Anttila, A Karjalainen… - Cancer research, 1998 - AACR
… lesion for lung cancer, expressed the Cox-2 protein. Our data, thus, suggest that Cox-2 is
ex pressed in human lung carcinomas and in precursor lesions leading to this malignancy. …

Cyclooxygenase-2 in lung cancer

SM Dubinett, S Sharma, M Huang… - Progress in …, 2003 - books.google.com
… These investigations in the molecular pathogenesis of lung cancer have presented …
Cyclooxygenase (COX)-2 is one of the novel targets under evaluation for lung cancer therapy and …

Multifaceted roles of cyclooxygenase-2 in lung cancer

K Riedl, K Krysan, M Põld, H Dalwadi… - Drug resistance …, 2004 - Elsevier
Lung cancer is the leading cause of cancer death in the United … cyclooxygenase-2 (COX-2)
is overexpressed in lung cancer … COX-2 inhibitors have been found to inhibit tumor growth in …

Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas

T Hida, Y Yatabe, H Achiwa, H Muramatsu, K Kozaki… - Cancer research, 1998 - AACR
… -2 expression in normal and neoplastia cells of the lung. We report here a detailed analysis
of COX-2 expression in 59 lung cancer … as in normal and premalignant lung specimens. The …

Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer

FR Khuri, H Wu, JJ Lee, BL Kemp, R Lotan… - Clinical cancer …, 2001 - AACR
Lung cancer is by far the leading cause of cancer-related death. Predictions are that 164,100
new cases of lung cancer and 156,900 deaths from lung cancer … rate for lung cancer has …

Cyclooxygenase2 (COX‐2) mRNA expression levels in normal lung tissues and non‐small cell lung cancers

M Ochiai, T Oguri, T Isobe, S Ishioka… - … journal of cancer …, 1999 - Wiley Online Library
… of COX-2 in lung cancers are still uncertain. Therefore, in this study we compared the gene
expression levels of COX-2 in non-small cell lung cancers (NSCLC) with those in normal lung

Cyclooxygenase-2 inhibitors in lung cancer

S Ramalingam, CP Belani - Clinical lung cancer, 2004 - Elsevier
… evaluating the utility of COX-2 inhibitors in the chemoprevention and treatment of several
cancers including lung cancer. In this article, we will review the role of COX-2 in lung cancer. …

Cyclooxygenase as a target in lung cancer

JR Brown, RN DuBois - Clinical Cancer Research, 2004 - AACR
… One such potential target is the cyclooxygenase (COX) … -2 isoform in the development of
some lung cancers. COX-… of cyclooxygenase 2 occurs frequently in human lung cancers, …

Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44

M Dohadwala, J Luo, L Zhu, Y Lin, GJ Dougherty… - Journal of Biological …, 2001 - ASBMB
… -small cell lung cancer (NSCLC). To assess the impact of COX-2 expression in lung cancer
… human COX-2 cDNA in the sense (COX-2-S) and antisense (COX-2-AS) orientations. COX-…