[HTML][HTML] Anti-trypanosomatid drug discovery: progress and challenges

M De Rycker, S Wyllie, D Horn, KD Read… - Nature Reviews …, 2023 - nature.com
… to facilitate studies of drug mechanisms of action… progress in drug discovery for kinetoplastid
diseases and how an improved understanding of parasite biology affects the drug discovery

Alchemical free energy methods for drug discovery: progress and challenges

JD Chodera, DL Mobley, MR Shirts, RW Dixon… - Current opinion in …, 2011 - Elsevier
… , we discuss a number of challenges that remain before these approaches can provide clear
utility in industrial drug discovery challenges where existing virtual screening approaches …

[PDF][PDF] Challenges in drug discovery: can we improve drug development

B Arun - Journal of Bioanalysis & Biomedicine, 2009 - hal.science
… This clearly points out that the various advancements in early drug discovery has increased
the pipeline … These approaches will probably improve our current lacunae in drug discovery. …

Drug repositioning: Progress and challenges in drug discovery for various diseases

Y Hua, X Dai, Y Xu, G Xing, H Liu, T Lu, Y Chen… - European Journal of …, 2022 - Elsevier
Compared with traditional de novo drug discovery, drug repurposing has become an attractive
drug discovery strategy due to its low-cost and high efficiency. Through a comprehensive …

Challenges for drug discovery and development in China

KL Hon, VWY Lee - Expert Opinion on Drug Discovery, 2017 - Taylor & Francis
… This overview summarize the challenges in drug discovery in China in anticancer,
antiallergy, anti-infectious, and pCM for various chronic diseases (such as the allergic diseases …

Current and future challenges in modern drug discovery

CS Tautermann - Quantum mechanics in drug discovery, 2020 - Springer
… , the drug discovery business looks … challenges in drug discovery. Because this article is
part of a book on quantum mechanics (QM) in drug design, I will clearly focus on the discovery of …

Leishmaniasis drug discovery: recent progress and challenges in assay development

B Zulfiqar, TB Shelper, VM Avery - Drug discovery today, 2017 - Elsevier
… for compound progression within the drug discovery pipeline have been determined as
the minimal requirements for the development of a safe, oral, effective anti-leishmanial drug, …

Progress and challenges in the discovery of macrofilaricidal drugs

TG Geary, CD Mackenzie - Expert review of anti-infective therapy, 2011 - Taylor & Francis
drug discovery pipelines are poorly populated and the process of macrofilaricide discovery
and development remains highly challengingdrug discovery pathway is an unresolved issue. …

Drug development and discovery: challenges and opportunities

M Moridani, S Harirforoosh - Drug discovery today, 2014 - Elsevier
… of drug development and discovery, the current communication discusses only the challenges
… companies and academic scientists over the course of drug discovery and development. …

[HTML][HTML] Deuterium in drug discovery: progress, opportunities and challenges

RMC Di Martino, BD Maxwell, T Pirali - Nature Reviews Drug Discovery, 2023 - nature.com
drug deucravacitinib in 2022. In this Review, we highlight key milestones in the field of
deuteration in drug discovery … the opportunities and hurdles for drug developers, as well as the …