… To strengthen our kinase drug discovery engine in this field, we constructed specially
designed chemical libraries for allosteric or covalent target inhibition. Moreover, we carefully …

… and discuss major challenges and opportunities of polypharmacology in drug discovery. In
… therapies, potential drug promiscuity arising from off-target effects, drug repurposing, and …

… Nevertheless, there are signs that drug discovery in the 21st century will see more intentional
government, academic and industrial collaborations to overcome the above challenges …

… We are in a new era of drug discovery. Areas covered: This review provides an overview of
the current status of academic drug discovery groups, their achievements and the challenges …

… relevant animal models in which to test new drugs. In this review, we aim to discuss some
of these issues at each stage of the drug discovery process, provide examples of recent work …

… Prodrugs should not be a ‘last resort’ but must be considered earlier in discovery when
teams are faced with challenging pharmaceutical or PK properties that cannot be addressed by …

… of drug repurposing for antiviral development, summarized the promising drug candidates
that … -spectrum activity, and analyzed the possible caveats of this strategy of drug discovery. …

… The success rate is less than 6% of new drug discovery and development, which is far
away … to accelerate drug discovery to advance the success rate of drug development. Drug …

… of innovative drugs which are progressing through clinical development. In this review, the
challenges associated with complement drug discovery are discussed and the current drug …

… from a more rational and systematic drug discovery and optimization approaches, which
will have a significant impact on drug discovery pipelines, and eventually on public health. …