[HTML][HTML] NF-κB activation: the IκB kinase revealed?
I Stancovski, D Baltimore - Cell, 1997 - cell.com
… subunits are members of the larger NF-κB/Rel family of This understanding of the sites and
… for the kinase (s) scription, our view of the role of NF-κB in immune and responsible for IκB …
… for the kinase (s) scription, our view of the role of NF-κB in immune and responsible for IκB …
How NF-κB is activated: the role of the IκB kinase (IKK) complex
M Karin - Oncogene, 1999 - nature.com
… of IκB. The key regulatory step in this pathway involves activation of a high molecular weight
IκB kinase (IKK) complex, whose catalysis is generally carried out by a heterodimeric kinase …
IκB kinase (IKK) complex, whose catalysis is generally carried out by a heterodimeric kinase …
[HTML][HTML] The beginning of the end: IκB kinase (IKK) and NF-κB activation
M Karin - Journal of Biological Chemistry, 1999 - ASBMB
… control of IκB phosphorylation in response to all other NF-κB activating stimuli rests on the
shoulders of the IκB kinase (… Once it became clear that the key step in NF-κB activation was IκB …
shoulders of the IκB kinase (… Once it became clear that the key step in NF-κB activation was IκB …
IκB kinase β (IKKβ/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-κB
JA Schmid, A Birbach - Cytokine & growth factor reviews, 2008 - Elsevier
… IKKβ turned out to be the crucial kinase of the IKK-signalosome for activation of NF-κB by
most inflammatory stimuli, which is considered the classical or canonical pathway of NF-κB …
most inflammatory stimuli, which is considered the classical or canonical pathway of NF-κB …
IκB kinase complexes: gateways to NF-κB activation and transcription
C Scheidereit - Oncogene, 2006 - nature.com
… NF-κB activation depends on phosphorylation-induced proteolysis of inhibitory IκB molecules
and NF-κB … diverse signaling pathways that activate NF-κB converge on IκB kinases (IKK), …
and NF-κB … diverse signaling pathways that activate NF-κB converge on IκB kinases (IKK), …
The IκB kinase complex: master regulator of NF-κB signaling
LA Solt, MJ May - Immunologic research, 2008 - Springer
… A pivotal regulator of all inducible NF-κB signaling pathways is the IκB kinase (IKK)
complex that consists of two kinases (IKKα and IKKβ) and a regulatory subunit named NF-κB …
complex that consists of two kinases (IKKα and IKKβ) and a regulatory subunit named NF-κB …
The IκB kinase complex in NF‐κB regulation and beyond
M Hinz, C Scheidereit - EMBO reports, 2014 - embopress.org
… IκB kinase‐mediated activation of NF‐κB is differentially regulated by IKKα and IKKβ. Both
kinases … identity), and contain an N‐terminal kinase domain, a dimerization domain and a C‐…
kinases … identity), and contain an N‐terminal kinase domain, a dimerization domain and a C‐…
IκB kinase: beginning, not the end
IM Verma, J Stevenson - Proceedings of the National …, 1997 - National Acad Sciences
… from the ubiquitination-inducible IκB kinase complex (18). Because the IκB kinase is unrelated
to MAP or Jun kinases, IKK represents a completely novel kinase pathway. The work to …
to MAP or Jun kinases, IKK represents a completely novel kinase pathway. The work to …
IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
JD Woronicz, X Gao, Z Cao, M Rothe, DV Goeddel - Science, 1997 - science.org
… kappa B (NF-κB) by inflammatory cytokines requires the successive action of NF-κB–inducing
kinase (NIK) and IκB kinase–α (IKK-α). A widely expressed protein kinase was identified …
kinase (NIK) and IκB kinase–α (IKK-α). A widely expressed protein kinase was identified …
The NF-κB pathway
PN Moynagh - Journal of cell science, 2005 - journals.biologists.com
… Activators of the IKK complex include mitogen-activated protein kinase kinase kinases (MAP3Ks)
such as MEKK1, MEKK3 and TAK1 and it represents a convergence point for …
such as MEKK1, MEKK3 and TAK1 and it represents a convergence point for …
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