… Osteoarthritis is characterized by deterioration and loss of articular cartilage and hallmarked
… physiology of joints, articular cartilage nutrition, and the etiology of cartilage destruction and …

… Although the initial changes in OA occur in the articular cartilage, all joint structures are
affected. The subchondral bone often already shows changes in the early stage of OA. …

… increased cartilage loss. In conclusion, assessment of cartilage and synovium metabolism
using … may be useful for assessing disease activity and joint damage in patients with knee OA, …

… However, the fact that some regrowth of cartilage on damaged joint surfaces may take place
at all is significant. If we are to use the apparently limited healing capacity of joint cartilage …

… concentrations of this cartilage marker reflect early changes in joint cartilage homeostasis
and, in … in a narrow zone of the subchondral bone juxtapositioned to the joint cartilage [15, 17]. …

… , induction of the proteolytic destruction of cartilage), it may be an … joint destruction rather
than tunneling in on the clinical endpoint (eg, joint space narrowing and pain, resulting in joint …

… The aim of this clinical biomarker analysis was to investigate the influence of inflammation
on cartilage destruction and metabolism. Methods. Patients with acute joint infections were …

… tissues, followed by a summary of current clinical applications of these metabolites in
rheumatic and degenerative joint diseases with emphasis on the most recent trends and research …

… understanding of the origins of joint pain and tests that allow for the evaluation of treatment
responses designed to arrest joint destruction and control pain [7]. In joint diseases, there is a …

… the cartilage proteoglycan aggrecan and type II collagen. We have also compared cartilage
metabolism … with advanced joint destruction than in patients with well preserved joints ( 17 ). …