A novel NF-κB-inducing kinase-MAPK signaling pathway up-regulates NF-κB activity in melanoma cells

P Dhawan, A Richmond - Journal of Biological Chemistry, 2002 - ASBMB
… of NF-κB as analyzed by EMSA analysis is constitutively high in most of the melanoma cell
lines … However, this constitutive NF-κB activation was almost 19-fold elevated in Hs294T …

NFκB activation in melanoma

Y Ueda, A Richmond - Pigment cell research, 2006 - Wiley Online Library
… in melanoma and upregulation of NF-κB, (ii) mechanisms by which activated NF-κB switch
Melanoma cells exposed to CCL27 undergo rapid activation of AKT and exhibit resistance …

NF-κB as potential target in the treatment of melanoma

G Madonna, CD Ullman, G Gentilcore… - Journal of translational …, 2012 - Springer
… This process overall entails a constitutive induction of NF-κB activity and an increased
survival of melanoma cells [23]. Combination of these data with others reported in literature …

The role of NF-κB in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells

AV Franco, XD Zhang, E Van Berkel… - The Journal of …, 2001 - journals.aai.org
… In the present study, we have assessed the role of NF-κB in susceptibility of melanoma cells
… which inhibit NF-κB activity. We also have generated TRAIL-resistant melanoma cells by …

Enhanced degradation of I-κBα contributes to endogenous activation of NF-κB in Hs294T melanoma cells

RL Shattuck-Brandt, A Richmond - Cancer research, 1997 - AACR
… malig nant melanoma cells, in part as a result of constitutive NF-… NF-KB complex in Hs294T
cells, the mRNA for I-KBa did not appear to be constitutively cx pressed. In unstimulated cells, …

Curcumin downregulates the constitutive activity of NF-κB and induces apoptosis in novel mouse melanoma cells

YE Marín, BA Wall, S Wang, J Namkoong… - Melanoma …, 2007 - journals.lww.com
… 10 melanoma cells when injected into animals, have been reported previously [ 30 ]. In this
study, we show that NF-κB is constitutively active in our novel melanoma cell … of NF-κB activity …

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives

Z Janjetovic, AA Brozyna, RC Tuckey, TK Kim… - British journal of …, 2011 - nature.com
… form of NF-κB in activated cells is a … NF-κB subunit in SKMEL-188 melanoma cells, we
prepared cytoplasmic and nuclear extracts from pigmented and nonpigmented melanoma cells. …

p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression

VN Ivanov, Z Ronai - Oncogene, 2000 - nature.com
melanoma cells p38 negatively regulates the expression of Fas. We demonstrate that this
negative regulation is mediated via suppression of NF-κB … in melanoma cells through positive …

Rapamycin inhibits doxorubicin-induced NF-κB/Rel nuclear activity and enhances the apoptosis of melanoma cells

MF Romano, R Avellino, A Petrella, R Bisogni… - European Journal of …, 2004 - Elsevier
NF-κB may be of therapeutic interest in melanoma. We found that rapamycin sensitised a
human melanoma cell … Doxorubicin is a striking NF-κB/Rel-inducer, we therefore investigated if …

Coordinate modulation of Sp1, NFkappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation

CR Yang, C Wilson-Van Patten… - The FASEB …, 2000 - Wiley Online Library
… Human malignant melanoma is often highly metastatic and radioresistant (1, 2). An established
human melanoma cell line (U1-Mel) that showed extreme radioresistance (1) and high …