Role of JAK-STAT and PPAR-gamma signalling modulators in the prevention of autism and neurological dysfunctions

R Khera, S Mehan, S Kumar, P Sethi, S Bhalla… - Molecular …, 2022 - Springer
… (STAT) signalling pathways regulate gene … signalling, prevents this phosphorylation and
aids in the treatment of the above-mentioned neurocomplications. Changes in cellular signalling

… /mTOR signaling in intracerebral hemorrhage: A systematic review on potential drug targets and influences of signaling modulators on other neurological disorders

KS Jadaun, A Sharma, EM Siddiqui… - Current Reviews in …, 2022 - ingentaconnect.com
… on the degree of mitochondrial dysfunction. Therefore in the … /mTOR signaling pathway
could minimize neuronal dysfunction … and dual PI3K/AKT/mTOR signaling pathway modulators. …

Calcium signalling: A common target in neurological disorders and neurogenesis

T Glaser, VFA Sampaio, C Lameu, H Ulrich - Seminars in cell & …, 2019 - Elsevier
… Despite the promising use of stem cell therapy coupled to Ca 2+ signalling modulation,
we … procedure by modulating the endogenous NPCs with the Ca 2+ signalling modulators. …

Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review

NK Jha, WC Chen, S Kumar, R Dubey… - Open …, 2022 - royalsocietypublishing.org
signalling pathways, especially in neurological disorders, has … In the recent past, the Shh
signalling pathway was reported … the Shh signalling pathway may be a significant modulator in …

Therapeutic modulators inhibiting neuromuscular and motor neuron degeneration

S Mehan - Frontiers in neuroscience, 2023 - frontiersin.org
… and cure these neurological dysfunctions. These achievements … signaling modulators to
prevent and diagnose MNDs. These cellular and molecular targets, as well as their modulators, …

Targeting sonic hedgehog signaling in neurological disorders

SS Patel, S Tomar, D Sharma, N Mahindroo… - Neuroscience & …, 2017 - Elsevier
… of small molecule modulators of Shh pathway with potential in neurological disorders. In …
potential of positive and negative regulators of the Shh pathway in neurological disorders. …

The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders

A Prajapati, S Mehan, Z Khan - Biogerontology, 2023 - Springer
… The initiation of the downstream signalling cascade through … and restoration during
neurological disorders. The … , a signalling molecule, was also essential in modulating the …

Regulation of dopamine signaling in the striatum by phosphodiesterase inhibitors: novel therapeutics to treat neurological and psychiatric disorders

AD Ramirez, SM Smith - … Nervous System Agents in Medicinal …, 2014 - ingentaconnect.com
… in modulating dopamine signaling and … disorders and Parkinson’s disease. The aim of this
review is to summarize the distinct roles of different PDEs in regulating dopamine signaling in …

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

P Jeffrey Conn, A Christopoulos… - Nature reviews Drug …, 2009 - nature.com
modulators may lead to novel therapeutic agents for treatment of multiple psychiatric and
neurological disorders, including anxiety disordersmodulator can perturb receptor signalling in …

Neuronal calcium signaling: function and dysfunction

M Brini, T Calì, D Ottolini, E Carafoli - Cellular and molecular life sciences, 2014 - Springer
… Ca 2+ signaling and its involvement in synaptic signaling … 2+ signaling in the most important
neurological disorders will … of channel expression and the modulation of current kinetics. The …