Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections

I Greco, AP Emborg, B Jana, N Molchanova, A Oddo… - Scientific Reports, 2019 - nature.com
… The aims of this study were to (i) characterize the antimicrobial activity of the novel
peptide-peptoid hybrid B1 against a large collection of two common dog integumentary pathogens S. …

Peptoid drug discovery and optimization via surface X‐ray scattering

K Andreev, MW Martynowycz, D Gidalevitz - Biopolymers, 2019 - Wiley Online Library
… We anticipate future optimizations into peptoids as therapeutics to be guided by more
complex systems of membrane mimetics such as surface X-ray scattering of supported lipid …

A field guide to optimizing peptoid synthesis

AM Clapperton, J Babi, H Tran - ACS Polymers Au, 2022 - ACS Publications
… (11,15,19,20,29,63) Here, we aim to highlight recent techniques used to optimize solution-phase
peptoid synthesis to improve polymerization, solubility, and synthetic versatility. …

Peptide/peptoid hybrid oligomers: The Influence of hydrophobicity and relative side-chain length on antibacterial activity and cell Selectivity

N Frederiksen, PR Hansen, F Björkling, H Franzyk - Molecules, 2019 - mdpi.com
… Previous optimisation studies of peptide/peptoid hybrids typically comprise comparison
of structurally related analogues displaying different oligomer length and diverse side chains. …

Structure-activity relationship study of novel peptoids that mimic the structure of antimicrobial peptides

B Mojsoska, RN Zuckermann… - Antimicrobial agents and …, 2015 - Am Soc Microbiol
… While fine-tuning the hydrophobicity, we have successfully optimized peptoid 1 by structural
rearrangement and single-monomer exchange and identified two candidates with high …

Alternating Cationic‐Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity

N Frederiksen, PR Hansen, D Zabicka… - …, 2020 - Wiley Online Library
… Ultimately, it was desirable to identify trends regarding how specific structural features may
be adjusted in order to optimise their potential therapeutic utility. Thus, we designed an initial …

Evaluation of peptoid mimics of short, lipophilic peptide antimicrobials

RM Green, KL Bicker - International journal of antimicrobial agents, 2020 - Elsevier
… of antimicrobial peptoids [9,25]. This study reports the synthesis and antimicrobial
efficacy of a series of peptoid derivatives of previously described α-peptides and β-peptides

Linker optimization and activity validation of a cell surface vimentin targeted homo-dimeric peptoid antagonist for lung cancer stem cells

H Zhang, DG Udugamasooriya - Bioorganic & Medicinal Chemistry, 2024 - Elsevier
… Our optimized highly CSV selective peptoid has the potential to be developed as an anti-cancer …
, especially considering the high serum stability and economical synthesis of peptoids. …

Lipidated α-peptide/β-peptoid hybrids with potent anti-inflammatory activity

SL Skovbakke, CJ Larsen, PMH Heegaard… - Journal of medicinal …, 2015 - ACS Publications
… , optimized, and characterized a novel subclass of host defense peptide (HDP) mimics
based on α-peptide/β-peptoid … Structure–activity studies revealed that certain lipidated α-peptide/β-…

Structure–Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its d- and l-Peptide Analogues

I Greco, JE Hansen, B Jana, N Molchanova, A Oddo… - Molecules, 2019 - mdpi.com
… we characterized the antimicrobial activity of the peptoid D2 against S. … –activity relationship
study of D2, which included 19 peptide/… We optimized its activity via a structure–activity study, …