… on occurrence and role of TMS genes in the published bacterial genome sequences. For
these reasons, we surveyed bacterial genomes for the presence of TMS genes using either the …

… the microbial genomes that are completely available including those that currently cannot be
assigned to a polyketide … We could detect PKS I genes in 27 of the 138 bacterial genomes …

… To further focus the analysis on a third level, we have analyzed the diversification of PKS in
a single bacterial genome. Here, we shortly summarize the results of our studies and discuss …

… This Review describes the impact of microbial genomics on natural products research, in …
systems called polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs), …

… polyketide (PK) and nonribosomal peptide (NRP) structures encoded in microbial genomes…
PKs/NRPs are polymers of carbonyl/peptidyl chains synthesized by polyketide synthases (…

… polyketides have … polyketide biosynthesis, termed type I polyketide synthases (PKSs) (42),
are so far known exclusively from microorganisms, it has long been suspected that bacteria …

… of microbial genomes led to discovery of novel bioactive compounds synthesized by NRPS
and PKS-I through genome-… field which directly studies microbial genomes or specific gene …

… Bacterial genome coverage is heavily biased toward pathogenic strains. Recent efforts
have attempted to obtain genomes from the poorly covered phylogenetic branches [18]. This …

… Type III polyketide synthases (PKS) were regarded as typical for plant secondary metabolism
before they were found in microorganisms recently. Due to microbial genome sequencing …

… chemotype-prediction rules for the analysis of type II PKS gene clusters observed in bacterial
genomes. These rules were effective in identifying novel candidates of type II PKS gene …