Engineering polyketide synthases and nonribosomal peptide synthetases
GJ Williams - Current opinion in structural biology, 2013 - Elsevier
… Polyketides and nonribosomal peptides are two large classes of natural products
biosynthesized by polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs), …
biosynthesized by polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs), …
Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics
… , with 281 citations, for the presence of genes encoding modular polyketide synthases (PKS)
and nonribosomal peptide synthetases (NRPS). We report on the distribution of these …
and nonribosomal peptide synthetases (NRPS). We report on the distribution of these …
Combinatorialization of fungal polyketide synthase–peptide synthetase hybrid proteins
TB Kakule, Z Lin, EW Schmidt - Journal of the American Chemical …, 2014 - ACS Publications
… The programming of the fungal polyketide synthase (PKS) is … peptide synthetase (NRPS)
to synthesize polyketides … correct formation of polyketide-peptide hybrid products. To do …
to synthesize polyketides … correct formation of polyketide-peptide hybrid products. To do …
The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
DE Cane, CT Walsh - Chemistry & biology, 1999 - cell.com
… polypeptide biosynthesis are known as polyketide synthases (PKSs) and nonribosomal
polypeptide … (One group of polyketides, the aromatic polyketides, are biosynthesized by a distinct …
polypeptide … (One group of polyketides, the aromatic polyketides, are biosynthesized by a distinct …
A Putative Polyketide Synthase/Peptide Synthetase from Magnaporthe grisea Signals Pathogen Attack to Resistant Rice
HU Böhnert, I Fudal, W Dioh, D Tharreau… - The Plant …, 2004 - academic.oup.com
… ACE1 was isolated by map-based cloning and encodes a putative hybrid between a
polyketide synthase and a nonribosomal peptide synthetase, enzymes involved in microbial …
polyketide synthase and a nonribosomal peptide synthetase, enzymes involved in microbial …
On the presence of peptide synthetase and polyketide synthase genes in the cyanobacterial genus Nodularia
MC Moffitt, BA Neilan - FEMS Microbiology Letters, 2001 - academic.oup.com
… the putative peptide synthetase and polyketide synthase regions. Sequencing of these
regions also gave strong similarity to other peptide synthetase and polyketide synthase regions …
regions also gave strong similarity to other peptide synthetase and polyketide synthase regions …
Polyketide synthase gene coupled to the peptide synthetase module involved in the biosynthesis of the cyclic heptapeptide microcystin
T Nishizawa, A Ueda, M Asayama, K Fujii… - The Journal of …, 2000 - academic.oup.com
… two polyketide synthase modules, and McyE contained a polyketide synthase module at
the N-terminus and a peptide synthetase module at the C-terminus. McyF was found to exhibit …
the N-terminus and a peptide synthetase module at the C-terminus. McyF was found to exhibit …
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
J Piel - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences
… encodes a mixed modular polyketide synthase/nonribosomal peptide synthetase. Notably,
none of … of additional polyketide synthase/nonribosomal peptide synthetase modules reveals …
none of … of additional polyketide synthase/nonribosomal peptide synthetase modules reveals …
[HTML][HTML] Phylogenetic study of polyketide synthases and nonribosomal peptide synthetases involved in the biosynthesis of mycotoxins
… in biosynthesis of polyketide and peptide toxins produced by … of the synthesis of
peptide-polyketide metabolites in fungi. The … the most important polyketide and peptide mycotoxins …
peptide-polyketide metabolites in fungi. The … the most important polyketide and peptide mycotoxins …
[HTML][HTML] Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase
… The lnm cluster spans 61.3 kb of DNA and consists of 27 genes encoding nonribosomal
peptide synthetase (NRPS), polyketide synthase (PKS), hybrid NRPS-PKS, resistance, …
peptide synthetase (NRPS), polyketide synthase (PKS), hybrid NRPS-PKS, resistance, …
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