Targeting PI3K-AKT/mTOR signaling in the prevention of autism
A Sharma, S Mehan - Neurochemistry international, 2021 - Elsevier
… therapeutic value for autism treatment. The current review also summarizes the involvement
of PI3K-AKT/mTOR signaling pathway inhibitors in the treatment of autism and other …
of PI3K-AKT/mTOR signaling pathway inhibitors in the treatment of autism and other …
Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders
J Chen, I Alberts, X Li - International Journal of Developmental …, 2014 - Elsevier
… /PI3K/AKT/mTOR signaling pathway and other related molecules mentioned in this review that
are involved in the regulation of autism … feedback role to prevent PI3K from returning to the …
are involved in the regulation of autism … feedback role to prevent PI3K from returning to the …
PI3K/AKT/mTOR-mediated autophagy in the development of autism spectrum disorder
J Zhang, JX Zhang, QL Zhang - Brain Research Bulletin, 2016 - Elsevier
… by PI3K/AKT/mTOR pathway. In agreement with this deduction, our study results showed
that the expression of PI3K/AKT/… PI3K/AKT/mTOR pathway. Taken together, we believed that …
that the expression of PI3K/AKT/… PI3K/AKT/mTOR pathway. Taken together, we believed that …
Mouse nerve growth factor suppresses neuronal apoptosis in valproic acid-induced autism spectrum disorder rats by regulating the phosphoinositide-3-kinase/serine …
J Jian, LG Li, PJ Zhao, RJ Zheng… - Pharmacogenetics …, 2023 - journals.lww.com
… In this study, we found that mNGF increased the phosphorylation of PI3K and Akt in the …
PI3K/Akt, we used the PI3K inhibitor LY294002. The result showed that inhibition of the PI3K/Akt …
PI3K/Akt, we used the PI3K inhibitor LY294002. The result showed that inhibition of the PI3K/Akt …
The putative etiology and prevention of autism
G Steinman - Progress in molecular biology and translational …, 2020 - Elsevier
… Compounding this could be neuronal cell signaling impediments in the PI3K/AKT/mTOR
pathway.32, 62 Initially, brain dysconnectivity in autism was discerned in 2004 to be between …
pathway.32, 62 Initially, brain dysconnectivity in autism was discerned in 2004 to be between …
The Autism‐Related lncRNA MSNP1AS Regulates Moesin Protein to Influence the RhoA, Rac1, and PI3K/Akt Pathways and Regulate the Structure and Survival of …
T Luo, JN Ou, LF Cao, XQ Peng, YM Li… - Autism …, 2020 - Wiley Online Library
… pathological changes in autism and that the PI3K/Akt signaling pathway played an important
role in the inhibition of apoptosis and promotion of neuronal survival in autism. Mammalian …
role in the inhibition of apoptosis and promotion of neuronal survival in autism. Mammalian …
[PDF][PDF] Roles of PTEN/PI3K/AKT/GSK3β pathway in neuron signaling involved in autism
A Minami, T Murai, A Nakanishi, Y Kitagishi… - Brain Disord …, 2015 - m.23michael.com
… B)/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway in brain … PI3K/AKT [10,11].
Here, we provide an overview of research on the characterization of the regulation of PI3K/AKT …
Here, we provide an overview of research on the characterization of the regulation of PI3K/AKT …
Early behavioral abnormalities and perinatal alterations of PTEN/AKT pathway in valproic acid autism model mice
… Since PTEN is a major regulator in the PI3K/AKT/mTOR pathway, we also measured the
changes in p-AKT and AKT to find that in E18 VPA hippocampus, the ratio of p-AKT/AKT was …
changes in p-AKT and AKT to find that in E18 VPA hippocampus, the ratio of p-AKT/AKT was …
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism …
… The recent findings imply that CPH also restores abnormal neurochemical levels and may
prevent autism-like gross pathological alterations, such as demyelination volume, in the rat …
prevent autism-like gross pathological alterations, such as demyelination volume, in the rat …
mTOR signaling disruption and its association with the development of autism spectrum disorder
… PI3K/Akt/mTOR pathway as well as the genetic alterations of the pathway components and
its critical impact on the development of the autism … found to prevent PI3K overactivation and …
its critical impact on the development of the autism … found to prevent PI3K overactivation and …
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