Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic.
Currently, there is only one modeling framework which can be applied to predict the …

OBJECTIVE: The composition of articular cartilage changes with progression of
osteoarthritis. Since compositional changes are associated with changes in the mechanical …

Objectives Current experimental approaches cannot elucidate the effect of maladaptive
changes on the main cartilage constituents during the degeneration process in osteoarthritis …

We present a novel algorithm combined with computational modeling to simulate the
development of knee osteoarthritis. The degeneration algorithm was based on excessive …

A subject‐specific collagen architecture of cartilage, obtained from T2 mapping of 3.0 T
magnetic resonance imaging (MRI; data from the Osteoarthritis Initiative), was implemented …

OBJECTIVE: Osteoarthritis (OA) is characterized by the changes in structure and
composition of articular cartilage. However, it is not fully known, what is the depth-wise …

Proteoglycans and collagen fibrils are distributed inhomogeneously throughout the depth of
articular cartilage, providing the tissue with its unique depth-dependent properties and …

It has been experimentally proposed that the discrete regions of articular cartilage, along
with different subchondral bone tissues, known as the bone-cartilage unit, are …

Objective Proteoglycan (PG) loss and surface roughening, early signs of osteoarthritis (OA),
are likely preceded by softening of the ground substance and the collagen network. Insight …

Cartilage defects are a known risk factor for osteoarthritis. Estimation of structural changes in
these defects could help us to identify high risk defects and thus to identify patients that are …