The expression of riboflavin transporters in human colorectal cancer

V Tutino, ML Defrancesco, M Tolomeo… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Riboflavin transport in enterocytes is mediated by three translocators:
RFVT3 located on the apical membrane, and RFVT1 and RFVT2 on the basolateral …

Evaluation of riboflavin transporters as targets for drug delivery and theranostics

L Bartmann, D Schumacher, S Von Stillfried… - Frontiers in …, 2019 - frontiersin.org
The retention and cellular internalization of drug delivery systems and theranostics for
cancer therapy can be improved by targeting molecules. Since an increased uptake of …

Flavin binding to the high affinity riboflavin transporter RibU

RH Duurkens, MB Tol, ER Geertsma… - Journal of Biological …, 2007 - ASBMB
The first biochemical and spectroscopic characterization of a purified membrane transporter
for riboflavin (vitamin B 2) is presented. The riboflavin transporter RibU from the bacterium …

Molecular and functional characterization of riboflavin specific transport system in rat brain capillary endothelial cells

M Patel, RK Vadlapatla, D Pal, AK Mitra - Brain research, 2012 - Elsevier
Riboflavin is an important water soluble vitamin (B2) required for metabolic reactions,
normal cellular growth, differentiation and function. Mammalian brain cells cannot …

Disruption of Slc52a3 gene causes neonatal lethality with riboflavin deficiency in mice

H Yoshimatsu, A Yonezawa, K Yamanishi, Y Yao… - Scientific reports, 2016 - nature.com
Homeostasis of riboflavin should be maintained by transporters. Previous in vitro studies
have elucidated basic information about riboflavin transporter RFVT3 encoded by SLC52A3 …

Current perspectives on the cellular uptake and trafficking of riboflavin

AB Foraker, CM Khantwal, PW Swaan - Advanced drug delivery reviews, 2003 - Elsevier
The role of riboflavin in cell maintenance and growth, and the mechanism by which it is
absorbed into various human tissues and cell lines has been extensively studied over the …

[HTML][HTML] Riboflavin phosphorylation is the crucial event in riboflavin transport by isolated rat enterocytes

G Gastaldi, G Ferrari, A Verri, U Laforenza… - The Journal of …, 2000 - Elsevier
In isolated rat enterocytes, both normoenergized (normal) and de-energized with rotenone,
riboflavin intracellular metabolic processes, operating in association with a membrane …

Transport functions of riboflavin carriers in the rat small intestine and colon: site difference and effects of tricyclic-type drugs

S Tomei, H Yuasa, K Inoue, J Watanabe - Drug Delivery, 2001 - Taylor & Francis
The present study was aimed at kinetically characterizing the newly found carrier-mediated
riboflavin transport system in the rat colon, comparing it with that in the small intestine, and …

Involvement of a receptor-mediated component in cellular translocation of riboflavin

SN Huang, PW Swaan - Journal of Pharmacology and Experimental …, 2000 - ASPET
This study addresses the transport mechanism of riboflavin (vitamin B2) across intestinal
epithelium in the presence and absence of pharmacologically active compounds. A …

Mechanism and regulation of riboflavin uptake by human renal proximal tubule epithelial cell line HK-2

CK Kumar, N Yanagawa, A Ortiz… - American Journal of …, 1998 - journals.physiology.org
Riboflavin (RF), a water-soluble vitamin, is essential for normal cellular functions, growth,
and development. Normal RF body homeostasis depends on intestinal absorption and …