Fetal neural progenitor grafts have been evaluated in preclinical animal models of spinal
cord injury and Parkinson's disease for decades, but the initial reliance on primary tissue as …

Neural stem and progenitor cell (NSPC) transplantation has emerged as a promising
therapeutic strategy for replacing lost neuronal populations and repairing damaged neural …

Retrograde monosynaptic tracing with EnvA-pseudotyped rabies virus has been employed
to identify the afferent and efferent connectivity of transplanted human embryonic stem (hES) …

Expectations for neural stem/progenitor cell (NS/PC) transplantation as a treatment for spinal
cord injury (SCI) are increasing. However, whether and how grafted cells are incorporated …

The functional synaptic integration of grafted stem cell-derived neurons is one of the key
aspects of neural cell replacement therapies for neurological disorders such as Parkinson's …

The ability of new neurons to promote repair of brain circuitry depends on their capacity to re-
establish afferent and efferent connections with the host. In this review article, we give an …

Pluripotent stem cells (embryonic stem cells, ESCs, and induced pluripotent stem cells,
iPSCs) have the capacity to generate neural progenitors that are intrinsically patterned to …

Neural stem/progenitor cell (NSPC) grafts can integrate into sites of spinal cord injury (SCI)
and generate neuronal relays across lesions that can provide functional benefit. To …

Key points• Ectopic cell transplantation for Parkinson's disease improves dopamine
neurotransmission but fails to restore the neural circuit important for controlled motor …

To repair neural circuitry following spinal cord injury (SCI), neural stem cell (NSC)
transplantation has held a primary focus; however, stochastic outcomes generate …