Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence,
disruption of essential protein kinase function has been explored for therapy of parasitic …

Abstract Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in
apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for …

Parasitic protozoa infecting humans have a great impact on public health, especially in the
developing countries. In many instances, the parasites have developed resistance against …

Inhibitors of cellular protein kinases have been reported to inhibit the development of
Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are …

The importance of protein kinases in cell signaling and cell cycle control has led to detailed
structural and functional studies in various eukaryotes, and hence to the synthesis of specific …

Parasitic infections caused by Plasmodium, Trypanosoma, Leishmania, Toxoplasma and
parasitic nematodes affect hundreds of millions of individuals worldwide and are the cause …

Specific roles of individual CDPKs vary, but in general they mediate essential biological
functions necessary for parasite survival. A comparative analysis of the structure-activity …

Apicomplexan parasites cause some of the most severe human diseases, including malaria
(caused by Plasmodium), toxoplasmosis, and cryptosporidiosis. Treatments are limited by …

Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites.
Many apicomplexan protein kinases are substantially different from their mammalian …

Parasitic protozoa infecting humans have a staggering impact on public health, especially in
the developing world. Furthermore, several protozoan species are major pathogens of …