An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …

X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …

Reactive Oxygen Species‐Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel …

Y Zeng, M Fan, Q Zhou, D Chen, T Jin… - Advanced Functional …, 2023 - Wiley Online Library
Abnormal activation of the gut mucosal immune system and a highly dysregulated gut
microbiota play essential roles in the progression of inflammatory bowel disease (IBD). The …

Orally administrated inflamed colon-targeted nanotherapeutics for inflammatory bowel disease treatment by oxidative stress level modulation in colitis

DK Min, YE Kim, MK Kim, SW Choi, N Park, J Kim - ACS nano, 2023 - ACS Publications
Inflammatory bowel disease (IBD) is characterized by an inappropriate and persistent
inflammatory immune response and is often accompanied by excessive reactive oxygen …

Berberine-loaded carboxylmethyl chitosan nanoparticles ameliorate DSS-induced colitis and remodel gut microbiota in mice

L Zhao, X Du, J Tian, X Kang, Y Li, W Dai… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is a refractory disorder characterized by chronic and
recurrent inflammation. The progression and pathogenesis of IBD is closely related to …

[HTML][HTML] Reactive oxygen species-responsive nanocarrier ameliorates murine colitis by intervening colonic innate and adaptive immune responses

X Yan, L Meng, X Zhang, Z Deng, B Gao, Y Zhang… - Molecular Therapy, 2023 - cell.com
Ulcerative colitis (UC) is a chronic or relapsing inflammatory disease with limited therapeutic
outcomes. Pterostilbene (PSB) is a polyphenol-based anti-oxidant that has received …

Nanoprobiotics for remolding the pro-inflammatory microenvironment and microbiome in the treatment of colitis

J Li, M Sun, L Liu, W Yang, A Sun, J Yu, D Liu… - Nano Letters, 2023 - ACS Publications
Despite the great progress of current bacterially based biotherapeutics, their unsatisfying
efficacy and underlying safety problems have limited their clinical application. Herein …

An engineered butyrate-derived polymer nanoplatform as a mucosa-healing enhancer potentiates the therapeutic effect of magnolol in inflammatory bowel disease

X Fan, Z Zhang, W Gao, Q Pan, K Luo, B He, Y Pu - ACS nano, 2023 - ACS Publications
Colonic epithelial damage and dysregulated immune response are crucial factors in the
progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted …

A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease

Q Zhang, H Tao, Y Lin, Y Hu, H An, D Zhang, S Feng… - Biomaterials, 2016 - Elsevier
Oxidative stress, resulting from excessive generation of reactive oxygen species (ROS),
plays a pivotal role in the initiation and progression of inflammatory bowel disease (IBD). To …

[HTML][HTML] Nitrate ameliorates dextran sodium sulfate-induced colitis by regulating the homeostasis of the intestinal microbiota

L Hu, L Jin, D Xia, Q Zhang, L Ma, H Zheng, T Xu… - Free Radical Biology …, 2020 - Elsevier
Inflammatory bowel disease (IBD) involves chronic inflammation, loss of epithelial integrity,
and gastrointestinal microbiota dysbiosis. Effective therapies for IBD have not been …

Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome

J Xu, J Xu, T Shi, Y Zhang, F Chen, C Yang… - Advanced …, 2023 - Wiley Online Library
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …