Background Therapeutic hypothermia (TH) is regarded as the most efficacious therapy for
neonatal hypoxic encephalopathy. However, limitations in previous systematic reviews and …

Objective To establish the evidence of therapeutic hypothermia for newborns with hypoxic
ischemic encephalopathy (HIE). Data Sources Cochrane Central Register of Controlled …

Background: Perinatal asphyxia and hypoxic-ischemic encephalopathy (HIE) represent
substantial sources of neonatal morbidity and mortality in low-and middle-income countries …

Background Hypoxic perinatal brain injury is caused by lack of oxygen to baby's brain and
can lead to death or permanent brain damage. However, the effectiveness of therapeutic …

Objectives To examine if therapeutic hypothermia reduces the composite outcome of death,
moderate or severe disability at 18 months or more after mild neonatal encephalopathy …

Background The objective of this study was to systematically review randomized trials
assessing therapeutic hypothermia as a treatment for term neonates with hypoxic ischemic …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Objective To determine whether moderate hypothermia after hypoxic-ischaemic
encephalopathy in neonates improves survival and neurological outcome at 18 months of …

Context: Therapeutic hypothermia is the recommended treatment for neonates with
moderate or severe hypoxic ischemic encephalopathy (HIE). There is an increasing trend to …

Objectives To systematically review the effectiveness, as determined by survival without
moderate to severe neurodevelopmental disability in infancy and childhood, and the safety …