Purpose To predict the temperature-composition phase diagram of solid dispersions (SDs)
through theoretical approaches using cinnarizine-Soluplus® SD as a model system and …

Solid dispersion technology has been widely explored to improve the solubility and
bioavailability of poorly water-soluble compounds. One of the critical drawbacks associated …

Amorphous solid dispersion (ASD) has been well known as a potential strategy to improve
the bioavailability and dissolution performance of poorly water-soluble drugs. The primary …

The objective of the present study was to define a systematic approach to design and
prepare solid dispersions of poorly water-soluble drug. The systematic approach can be …

Introduction: Solid dispersion has been considered to be one of the most promising methods
for improving the solubility and bioavailability of insoluble drugs. However, the physical …

Solid dispersion has been a topic of interest in recent years for its potential in improving oral
bioavailability, especially for poorly water soluble drugs where dissolution could be the rate …

The purpose of this work was to compare the effect of temperature and relative humidity
(RH) on the physical stability and dissolution of solid dispersions. Cinnarizine-Soluplus® …

Drug–polymer miscibility is one of the fundamental prerequisite for the successful design
and development of amorphous solid dispersion formulation. The purpose of the present …

The objective of the present investigations was to assess the use of thermodynamic phase
diagrams and the Gibbs free energy of mixing, ΔG mix, for the screening of the polymeric …

Multiple carriers may be used to prepare solid dispersions (SDs) for different purposes. The
aim of this work is to investigate the effect of the third component on the physical stability and …