ROS responsive polydopamine nanoparticles to relieve oxidative stress and inflammation for ameliorating acute inflammatory bowel

M Yan, L Zhu, S Wu, Y Cao, N Mou, Q Chi, G Wang… - Biomaterials …, 2022 - Elsevier
Oxidative stress is a key factor in the development of inflammatory diseases. Elimination of
reactive oxygen species (ROS) in the inflamed colon has been confirmed as an effective …

ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease

M Bao, K Wang, J Li, Y Li, H Zhu, M Lu, Y Zhang… - Acta Biomaterialia, 2023 - Elsevier
Dysfunction of the intestinal mucosal immune system and dysbiosis of the intestinal
microflora can induce inflammatory bowel disease. However, drug-mediated clinical …

Polydopamine modified ceria nanorods alleviate inflammation in colitis by scavenging ROS and regulating macrophage M2 polarization

B Zhang, Q Li, Q Xu, B Li, H Dong… - International Journal of …, 2023 - Taylor & Francis
Background Inflammatory bowel disease (IBD) is closely related to higher intracellular
oxidative stress. Therefore, developing a novel method to scavenge the harmful reactive …

[HTML][HTML] A mesoporous polydopamine-derived nanomedicine for targeted and synergistic treatment of inflammatory bowel disease by pH-Responsive drug release …

H Guan, Z Xu, G Du, Q Liu, Q Tan, Y Chen, S Chen… - Materials Today Bio, 2023 - Elsevier
Repurposing clinically approved drugs to construct novel nanomedicines is currently a very
attractive therapeutic approach. Selective enrichment of anti-inflammatory drugs and …

Reactive oxygen species-responsive polyether micelle nanomaterials for targeted treatment of ulcerative colitis

XX Zhao, SB Ma, JP Wen, DT Hu… - Journal of …, 2022 - ingentaconnect.com
As one of the most challenging inflammatory diseases, the incidence of ulcerative colitis
(UC) is increasing year by year, but the existing therapeutic drugs are not effective and lack …

[HTML][HTML] Reactive oxygen species-responsive nanocarrier ameliorates murine colitis by intervening colonic innate and adaptive immune responses

X Yan, L Meng, X Zhang, Z Deng, B Gao, Y Zhang… - Molecular Therapy, 2023 - cell.com
Ulcerative colitis (UC) is a chronic or relapsing inflammatory disease with limited therapeutic
outcomes. Pterostilbene (PSB) is a polyphenol-based anti-oxidant that has received …

ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation

D Wang, Q Jiang, R Shen, L Peng, W Zhou, T Meng… - Nano Research, 2024 - Springer
The destruction of the intestinal barrier is likely to cause an increase in intestinal
permeability and cause pathological damage. Numerous studies have demonstrated that …

Self-polymerized polydopamine-based nanoparticles for acute kidney injury treatment through inhibiting oxidative damages and inflammatory

B Zheng, G Deng, J Zheng, Y Li, B Wang, X Ding… - … International Journal of …, 2022 - Elsevier
The polydopamine nanoparticles (PDA NPs) as a self-polymerized form of dopamine have
occurred with growing interest in biomedical applications in late years. Its natural-inspired …

Inflammation-targeting polyamine nanomedicines for the treatment of ulcerative colitis

A Nishiguchi, T Taguchi - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by
immune system dysfunction. Despite the availability of various anti-inflammatory drugs, they …

Nanoparticles derived from the natural antioxidant rosmarinic acid ameliorate acute inflammatory bowel disease

CH Chung, W Jung, H Keum, TW Kim, S Jon - Acs Nano, 2020 - ACS Publications
Rosmarinic acid (RA), one of the most important polyphenol-based antioxidants, has
received growing interest because of its bioactive properties, including anti-inflammatory …