UVB irradiation inhibits melanocyte proliferation by causing arrest in G1 (D. Barker, K. Dixon,
EE Medrano, D. Smalara, S. Im, D. Mitchell, G. Babcock, and ZA Abdel-Malek. Cancer Res …

In a search for effectors and targets of UVB signaling in mammalian cells, we screened a
keratinocyte cDNA library with differentially subtracted UVB-enriched cDNA probes. One of …

In order to identify potential novel targets for ultraviolet-B-induced skin tumorigenesis, we
assessed the effect of ultraviolet-B exposure on cell cycle progression of transformed …

Skin cancer is the most common cancer in the United States. Ultraviolet B (UVB) radiation in
sunlight is the major environmental factor causing skin cancer. p21, a p53-inducible protein …

Control of fate of cells encountered with DNA damaging agents is pivotal for normal cellular
homeostasis. DNA damage leads in many cases to growth arrest of the cells ensuring …

UV radiation-induced mutation of the p53 gene is suggested as a causative event in skin
cancer, including melanoma. We have analyzed here p53 mutations in melanoma cell lines …

The activation of cell cycle checkpoints in response to genotoxic stressors is essential for the
maintenance of genomic integrity. Although most prior studies of cell cycle effects of UV …

It is well established that the initiation of G 1 arrest in cultured cells exposed to ionizing
radiation (IR) is fully dependent upon the p53/p21waf1/pRb signaling cascade. However …

The ultraviolet B (UVB) portion (280–320 nm) of solar radiation is considered to be a major
etiologic factor in human skin cancer and is a known cause of extensive DNA damage. In …

Purpose: To examine the wavelength dependence of cellular responses in human
melanocytes and human melanoma cells exposed to ultraviolet radiation (UVR). Materials …