Gene repair involving in vivo excision of targeting DNA
A Choulika, RC Mulligan - US Patent 7,285,538, 2007 - Google Patents
US7285538B2 - Gene repair involving in vivo excision of targeting DNA - Google Patents
US7285538B2 - Gene repair involving in vivo excision of targeting DNA - Google Patents …
US7285538B2 - Gene repair involving in vivo excision of targeting DNA - Google Patents …
Gene repair involving the induction of double-stranded DNA cleavage at a chromosomal target site
A Choulika, R Mulligan - US Patent App. 09/917,295, 2002 - Google Patents
Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal
DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a …
DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a …
Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site
A Choulika, RC Mulligan - US Patent 9,458,439, 2016 - Google Patents
US9458439B2 - Chromosomal modification involving the induction of double-stranded DNA
cleavage and homologous recombination at the cleavage site - Google Patents US9458439B2 …
cleavage and homologous recombination at the cleavage site - Google Patents US9458439B2 …
Gene repair involving in vivo excision of targeting DNA
A Choulika, R Mulligan - US Patent App. 09/922,495, 2002 - Google Patents
The present invention is related to Applicants discovery that excision of targeting or
correcting DNA from a vector within cells which have taken up the vector Sig nificantly …
correcting DNA from a vector within cells which have taken up the vector Sig nificantly …
Gene repair involving the induction of double-stranded DNA cleavage at a chromosomal target site
A Choulika, R Mulligan - US Patent App. 10/337,229, 2004 - Google Patents
The present invention is related to Applicants discovery that induction of double stranded
DNA cleavage at a specific Site in chromosomal DNA induces a cellular repair mechanism …
DNA cleavage at a specific Site in chromosomal DNA induces a cellular repair mechanism …
Methods for repairing degraded DNA
MW Eshoo - US Patent 7,811,753, 2010 - Google Patents
US7811753B2 - Methods for repairing degraded DNA - Google Patents US7811753B2 -
Methods for repairing degraded DNA - Google Patents Methods for repairing degraded …
Methods for repairing degraded DNA - Google Patents Methods for repairing degraded …
Methods and compositions for targeted genomic deletion
F Urnov, J Wang - US Patent App. 13/310,263, 2012 - Google Patents
BACKGROUND 0003. A major area of interest in genome biology, espe cially in light of the
determination of the complete nucleotide sequences of a number of genomes, is the …
determination of the complete nucleotide sequences of a number of genomes, is the …
Use of chimeric nucleases to stimulate gene targeting
D Baltimore, M Porteus - US Patent 9,447,434, 2016 - Google Patents
Gene targeting is a technique to introduce genetic change into one or more specific
locations in the genome of a cell. For example, gene targeting can introduce genetic change …
locations in the genome of a cell. For example, gene targeting can introduce genetic change …
Methods and compositions for inactivation of dihydrofolate reductase
T Collingwood - US Patent App. 11/804,222, 2008 - Google Patents
BACKGROUND 0004 Various methods and compositions for targeted cleavage of genomic
DNA have been described. Such tar geted cleavage events can be used, for example, to …
DNA have been described. Such tar geted cleavage events can be used, for example, to …
Methods and compositions for targeted single-stranded cleavage and targeted integration
J Wang - US Patent 8,703,489, 2014 - Google Patents
US8703489B2 - Methods and compositions for targeted single-stranded cleavage and
targeted integration - Google Patents US8703489B2 - Methods and compositions for targeted …
targeted integration - Google Patents US8703489B2 - Methods and compositions for targeted …