The origin of pain in osteoarthritis is poorly understood, but it is generally thought to arise
from inflammation within the innervated structures of the joint, such as the synovium, capsule …

Background Nerve growth factor (NGF) is not only an important factor in nerve growth but
also a major contributor to the production of inflammation. It has been reported that inhibiting …

Osteoarthritis (OA) is a chronic degenerative musculoskeletal disease that causes articular
cartilage degeneration and chronic pain. Research into OA animal models suggests that …

Background Anti-nerve growth factor (NGF) monoclonal antibodies (anti-NGF mAbs) have
been reported to significantly attenuate pain, but the mechanism involved has not been fully …

A contributing role of nerve growth factor (NGF)‐mediated neuroimmunologic mechanisms
has provided a new dimension in the understanding of various cutaneous and systemic …

Objective To identify the role of mature nerve growth factor (mNGF), its immature form
proNGF and their receptors in arthritis inflammation. Methods Real-time PCR, western blot …

Background Nerve growth factor (NGF) plays a key role in osteoarthritic pain and low back
pain. Rotator cuff tear (RCT) is often associated with severe shoulder pain. However, the …

Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been
identified as therapeutic targets to improve current treatments of chronic pain. This review …

Pain often accompanies cancer and most current therapies for treating cancer pain have
significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate …

Background Nerve growth factor (NGF) plays a crucial role in pain modulation and is being
considered as a new therapeutic target for pain therapy. The purpose of this meta-analysis …