Objectives Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis
(OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a …

Background Rotator cuff tears (RCTs) are often associated with severe shoulder pain. Non-
steroidal anti-inflammatory drugs, not recommended for long-term use, do not effectively …

Objectives: Investigating the role of nerve growth factor (NGF) and its receptors (NGF‐R) in
inflammatory diseases is an active field of research. Inflammatory diseases of the joint are …

Objectives Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth
factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory …

Nerve growth factor (a-NGF) inhibitors have been developed for pain treatment including
symptomatic osteoarthritis (OA) and have proven analgesic efficacy and improvement in …

Background Biologic drugs are novel therapeutic agents with demonstrated effectiveness in
the management of a variety of chronic inflammatory disorders. Unmet needs in the …

Nerve growth factor (NGF) antagonism has long been proposed as a chronic pain treatment.
In 2010, the FDA suspended clinical trials using tanezumab, a humanized monoclonal anti …

Chronic pain arising from various pathological conditions such as osteoarthritis, low back or
spinal injuries, cancer, and urological chronic pelvic pain syndromes presents significant …

Objectives A key clinical paradox in osteoarthritis (OA), a prevalent age-related joint disorder
characterised by cartilage degeneration and debilitating pain, is that the severity of joint pain …

Osteoarthritis (OA) is a common difficult-to-treat condition where the goal, in the absence of
disease-modifying treatments, is to alleviate symptoms such as pain and loss of function …