Paclitaxel (Taxol®) is a widely used chemotherapeutic agent that has a major dose limiting
side-effect of painful peripheral neuropathy. Currently there is no effective therapy for the …

Chemotherapy-induced neuropathic pain is a significant side effect of chemotherapeutic
agents and is the most common reason for stopping chemotherapy. The aim of the present …

Spinal glial cells contribute to the development of many types of inflammatory and
neuropathic pain. Here the contribution of spinal astrocytes and astrocyte gap junctions to …

To clarify the role of peroxisome proliferator activated receptor γ (PPARγ) in neuropathic
pain, we examined the effect of pioglitazone, a PPARγ agonist, on tactile allodynia and …

Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose-and therapy-
limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we …

We describe an animal model of nociceptive sensory neuropathy induced by repeat
intravenous administration of oxaliplatin in which treated animals partly reproduce the …

Background Chemotherapy induced peripheral neuropathy (CIPN) has been attributed to
chemotherapeutic agents such as cisplatin which adversely affect disease outcome leading …

A 3 AR agonists prevent paclitaxel-induced neuropathic pain via modulating spinal redox-
dependent signaling pathways (restoring glutamatergic homeostasis, attenuating …

Cancer is a global health problem that is often successfully addressed by therapy, with
cancer survivors increasing in numbers and living longer world around. Although new …

Activation of toll-like receptor 4 (TLR4) in the dorsal root ganglion (DRG) and spinal cord
contributes to the generation of paclitaxelrelated chemotherapy-induced peripheral …