Background: Cisplatin, a platinum-derived chemotherapeutic agent, produces antineoplastic
effects coupled with toxic neuropathic pain and impaired general health status. These side …

Bone cancer pain (BCP) is a serious clinical problem that affects the quality of life of cancer
patients. However, the current treatment methods for this condition are still unsatisfactory …

Background Paclitaxel is an antimitotic antitumour drug highly effective against a broad
range of cancers considered refractory to conventional chemotherapy. One of the main …

Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a critical
factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and …

Simple Summary Paclitaxel, a drug used in the treatment of malignancies such as lung,
ovarian and breast cancer, often produces severe side effects, among which is peripheral …

Purpose Cisplatin-treated mice develop a persistent pain state and a condition wherein
otherwise innocuous tactile stimuli evoke pain behavior, eg, tactile allodynia. The allodynia …

Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …

Many commonly used chemotherapeutics including oxaliplatin are associated with the
development of a painful chemotherapy-induced peripheral neuropathy (CIPN). This dose …

Chemotherapy‑induced peripheral neuropathic pain (CIPNP) is a serious, undesirable effect
of cancer treatment which is particularly difficult to prevent. Berberine and its derivatives …

In clinical use, a single infusion of oxaliplatin, widely used to treat metastatic colorectal
cancer, induces specific sensory neurotoxicity signs triggered or aggravated by exposure to …