Chemokines comprise a superfamily of at least 46 cytokines that were initially described
based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed …

Malignant cells from at least 23 different types of cancer express the chemokine receptor
CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved …

CXCR4 is a member of the chemokine receptor subfamily of seven transmembrane
domained, G-protein coupled receptors, whose sole known natural ligand is CXCL12/SDF …

The chemotactic cytokines called chemokines are a superfamily of small secreted cytokines
that were initially characterized through their ability to prompt the migration of leukocytes …

Chemokines are a class of small cytokines or signaling proteins that are secreted by cells.
Owing to their ability to induce directional chemotaxis of nearby responding cells, they are …

Breast tumor cells express the chemokine receptor CXCR3, which binds the ligands CXCL9,
CXCL10, and CXCL11. CXCR3 and other chemokine receptors may mediate tumor …

CXCR4 and its ligand CXCL12 can promote the proliferation, survival, and invasion of
cancer cells. They have been shown to play an important role in regulating metastasis of …

Compelling evidence shows that chemokine CXC motif chemokine ligand 12 (CXCL12)
drives metastasis in multiple malignancies. Similar to other key cytokines in cancer, CXCL12 …

Chemokines are small, secreted proteins and are now the largest known cytokine family.
They mediate their effects through a family of G-protein-coupled receptors and were initially …

The acquisition of a metastatic phenotype in breast epithelial cells is a progressive process,
influenced by a large variety of cellular and soluble factors. Of these, members of the …