Objectives To systematically review the effectiveness, as determined by survival without
moderate to severe neurodevelopmental disability in infancy and childhood, and the safety …

Objective To establish the evidence of therapeutic hypothermia for newborns with hypoxic
ischemic encephalopathy (HIE). Data Sources Cochrane Central Register of Controlled …

Neonatal encephalopathy affects 2 to 5 of every 1000 live births and represents a major
cause of mortality and long-term morbidity in affected infants. Hypoxic ischemic …

Hypoxic ischemic encephalopathy (HIE) remains a significant cause of mortality and long-
term disability in late preterm and term infants. Mild therapeutic hypothermia to a rectal …

Background The objective of this study was to systematically review randomized trials
assessing therapeutic hypothermia as a treatment for term neonates with hypoxic ischemic …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Hypothermia is a potential neuroprotective intervention to treat neonatal post-asphyxial
(hypoxic–ischemic) encephalopathy (HIE). In this meta-analysis of 13 clinical trials …

Moderate to severe hypoxic–ischemic injury in newborn infants, manifested as
encephalopathy immediately or within hours after birth, is associated with a high risk of …

Therapeutic hypothermia is now the standard of care for brain injury control in term infants
with perinatal hypoxic ischemic encephalopathy (HIE). Accumulated evidence shows a …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …