Background: Levosimendan is a calcium sensitizer drug causing increased contractility in
the myocardium and vasodilation in the vascular system. It is mainly used for the therapy of …

Levosimendan is a calcium sensitizer and adenosine triphosphate–dependent potassium
channel opener, which exerts sustained hemodynamic, symptomatic, and organ-protective …

Background The role of prophylactic levosimendan in patients undergoing cardiac surgery is
controversial. Methods We performed a computerized search of Medline, Embase, and …

Introduction Levosimendan is implemented in patients with low cardiac output after cardiac
surgery. However, the strength of evidence is limited by randomized controlled trials …

In cardiac surgery, postoperative low cardiac output has been shown to correlate with
increased rates of organ failure and mortality. Catecholamines have been the standard …

Severe postoperative complications can affect cardiac surgery patients. Levosimendan is a
novel calcium sensitizer commonly administered after cardiac surgery. However, the patient …

Objective Left ventricular systolic dysfunction is associated with increased morbidity and
mortality in patients undergoing cardiac surgery. The authors performed a meta-analysis …

Purpose Though a subgroup analysis has shown improved survival for patients suffering
severely reduced ventricular function undergoing coronary artery bypass grafting, RCTs …

Background Acute left ventricular dysfunction is a major complication of cardiac surgery and
is associated with increased mortality. Meta-analyses of small trials suggest that …

Background Several studies suggested beneficial effects of perioperative levosimendan on
postoperative outcome after cardiac surgery. However, three large randomized controlled …