Malignant pleural effusion cells show aberrant glucose metabolism gene expression

CC Lin, LC Chen, VS Tseng, JJ Yan… - European …, 2011 - Eur Respiratory Soc
Malignant pleural effusion (MPE) accompanying lung adenocarcinoma indicates poor
prognosis and early metastasis. This study aimed to identify genes related to MPE formation …

Molecular profiling of malignant pleural effusion in metastatic non–small-cell lung carcinoma. The effect of preanalytical factors

J Carter, JA Miller, D Feller-Kopman… - Annals of the …, 2017 - atsjournals.org
Rationale: Non–small-cell lung cancer (NSCLC)–associated malignant pleural effusions
(MPEs) are sometimes the only available specimens for molecular analysis. Objectives: This …

Single‐cell transcriptomics reveal metastatic CLDN4+ cancer cells underlying the recurrence of malignant pleural effusion in patients with advanced non‐small‐cell …

X Zhang, X Wang, Y Wen, S Chen… - Clinical and …, 2024 - Wiley Online Library
Background Recurrent malignant pleural effusion (MPE) resulting from non‐small‐cell lung
cancer (NSCLC) is easily refractory to conventional therapeutics and lacks predictive …

ALDH1 and SALL4 expression in cell block samples from patients with lung adenocarcinoma and malignant pleural effusion

T Kanayama, T Taniguchi, H Tomita, A Niwa… - Diagnostics, 2021 - mdpi.com
Malignant pleural effusion (MPE) can accompany advanced lung adenocarcinoma. Recent
studies suggest that MPE could contain a heterogeneous subpopulation of cells with stem …

Pulmonary adenocarcinoma in malignant pleural effusion enriches cancer stem cell properties during metastatic cascade

SF Chen, YS Lin, SW Jao, YC Chang, CL Liu, YJ Lin… - PloS one, 2013 - journals.plos.org
Background Metastasis occurs in a series of discrete steps involving invasion, angiogenesis,
lymphovascular space permeation, and establishment of secondary tumors. Malignant …

mRNA markers associated with malignant pleural effusion

SC Hsu, SY Chang, YT Hwang, HJ Terng, CL Tsai… - Scientific Reports, 2023 - nature.com
Malignant pleural effusions (MPE) commonly result from malignant tumors and represent
advanced-stage cancers. Thus, in clinical practice, early recognition of MPE is valuable …

A multicancer malignant pleural effusion diagnostic test using hexokinase 2 and single-cell sequencing

J Chen, Y Yang, Z Wang, X Shen, Z Zhang… - Clinical …, 2022 - academic.oup.com
Background Malignant pleural effusion (MPE) represents advanced malignant disease with
poor prognosis. To date, pleural effusion cytology remains the best test to diagnose MPE but …

[HTML][HTML] Multiplexed molecular profiling of lung cancer using pleural effusion

H Akamatsu, Y Koh, H Kenmotsu, T Naito… - Journal of Thoracic …, 2014 - Elsevier
Introduction: Pleural effusion is frequently observed in patients with advanced lung cancer.
Although effusion can be obtained less invasively and repeatedly, its use in multiplexed …

Molecular profiling of malignant pleural effusions with next generation sequencing (NGS): evidence that supports its role in cancer management

GΙ Grigoriadou, SM Esagian, HS Ryu… - Journal of Personalized …, 2020 - mdpi.com
Malignant pleural effusions (MPEs) often develop in advanced cancer patients and confer
significant morbidity and mortality. In this review, we evaluated whether molecular profiling …

Pleural effusion in lung cancer: more questions than answers

ME Froudarakis - Respiration, 2012 - karger.com
Lung cancer remains the most common fatal malignancy, despite more aggressive
therapies. Few patients will survive 5 years, as up to 80% of the patients will present with …