Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases

J Liu, Y Wang, WJ Heelan, Y Chen, Z Li, Q Hu - Science advances, 2022 - science.org
Inflammatory bowel diseases (IBDs) are often associated with elevated levels of reactive
oxygen species (ROS) and highly dysregulated gut microbiota. In this study, we synthesized …

Modified prebiotic-based “shield” armed probiotics with enhanced resistance of gastrointestinal stresses and prolonged intestinal retention for synergistic alleviation of …

A Xie, H Ji, Z Liu, Y Wan, X Zhang, H Xiong, SP Nie… - ACS …, 2023 - ACS Publications
Oral administration of probiotics is a promising method to alleviate inflammatory bowel
diseases (IBDs). However, gastrointestinal environmental sensitivity and inferior intestinal …

Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

J Zhou, M Li, Q Chen, X Li, L Chen, Z Dong… - Nature …, 2022 - nature.com
Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore,
eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and …

Responsively Degradable Nanoarmor‐Assisted Super Resistance and Stable Colonization of Probiotics for Enhanced Inflammation‐Targeted Delivery

L Zhu, T Yu, W Wang, T Xu, W Geng, N Li… - Advanced …, 2024 - Wiley Online Library
Manipulation of the gut microbiota using oral microecological preparations has shown great
promise in treating various inflammatory disorders. However, delivering these preparations …

Prodrug integrated envelope on probiotics to enhance target therapy for ulcerative colitis

K Zhang, L Zhu, Y Zhong, L Xu, C Lang… - Advanced …, 2023 - Wiley Online Library
Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders
of the gut microbiota. Probiotics‐based therapy positively regulating the community structure …

[HTML][HTML] Reactive oxygen species-responsive nanocarrier ameliorates murine colitis by intervening colonic innate and adaptive immune responses

X Yan, L Meng, X Zhang, Z Deng, B Gao, Y Zhang… - Molecular Therapy, 2023 - cell.com
Ulcerative colitis (UC) is a chronic or relapsing inflammatory disease with limited therapeutic
outcomes. Pterostilbene (PSB) is a polyphenol-based anti-oxidant that has received …

Colon-Targeting Angelica sinensis Polysaccharide Nanoparticles with Dual Responsiveness for Alleviation of Ulcerative Colitis

Y Xu, BW Zhu, R Sun, X Li, D Wu… - ACS Applied Materials & …, 2023 - ACS Publications
Intestinal immune dysfunction and gut microbiota dysbiosis are critically causative factors in
the pathogenesis of ulcerative colitis (UC); however, the current first-line drugs for UC …

Gastrointestinal Microenvironment Responsive Nanoencapsulation of Probiotics and Drugs for Synergistic Therapy of Intestinal Diseases

P Peng, T Feng, X Yang, C Nie, L Yu, R Ding, Q Zhou… - ACS …, 2023 - ACS Publications
The gut microbiota are prominent in preserving intestinal environmental homeostasis and
managing human health, and their dysbiosis has been directly related to many kinds of …

Stimulation-responsive mucoadhesive probiotics for inflammatory bowel disease treatment by scavenging reactive oxygen species and regulating gut microbiota

QX Huang, JL Liang, CH Yang, K Li, MT Niu, JX Fan… - Biomaterials, 2023 - Elsevier
Inflammatory bowel disease (IBD) is characterized by the high level of reactive oxygen
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …

Reactive Oxygen Species‐Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel …

Y Zeng, M Fan, Q Zhou, D Chen, T Jin… - Advanced Functional …, 2023 - Wiley Online Library
Abnormal activation of the gut mucosal immune system and a highly dysregulated gut
microbiota play essential roles in the progression of inflammatory bowel disease (IBD). The …