Regulation of transcriptional responses in growth‐arrested human cells under conditions
that promote potentially lethal damage repair after ionizing radiation (IR) is poorly …

Over the past 15 years, a wealth of information has been published on transcripts and
proteins 'induced'(requiring new protein synthesis) in mammalian cells after ionizing …

In mammalian cells, activation of certain checkpoint pathways as a result of exposure to
genotoxic agents results in cell cycle arrest. The integrity of these arrest pathways is critical …

The transcription factor nuclear factor-κB (NF-κB) regulates cell survival pathways, but the
molecular mechanisms involved are not completely understood. Here, we developed a NF …

It is well established that the initiation of G 1 arrest in cultured cells exposed to ionizing
radiation (IR) is fully dependent upon the p53/p21waf1/pRb signaling cascade. However …

The fate of cells exposed to ionizing radiation (IR) may depend greatly on changes in gene
expression, so that an improved view of gene induction profiles is important for …

Many tumors show a mutant or inactive tumor suppressor p53 (TP53) status, and TP53 in the
tumor-carrying human papillomavirus (HPV) may be dysfunctional because of inhibition by …

While the precise mechanisms of melanoma development are unknown, recent in vivo
studies have revealed that the p16 Ink4a/Rb pathway is disrupted in melanomagenesis …

UVB irradiation inhibits melanocyte proliferation by causing arrest in G1 (D. Barker, K. Dixon,
EE Medrano, D. Smalara, S. Im, D. Mitchell, G. Babcock, and ZA Abdel-Malek. Cancer Res …

Adaptive survival responses (ASRs) are observed when cells become more resistant to a
high dose of a cytotoxic agent after repeated low dose exposures to that agent or another …